The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its apparent continuity, the cingulum’s composition continually changes as fibres join and leave the bundle. To help understand its complex structure, this review begins with detailed, comparative descriptions of the multiple connections comprising the cingulum bundle. Next, the impact of cingulum bundle damage in rats, monkeys, and humans is analysed. Despite causing extensive anatomical disconnections, cingulum bundle lesions typically produce only mild deficits, highlighting the importance of parallel pathways and the distributed nature of its various functions. Meanwhile, non-invasive imaging implicates the cingulum bundle in executive control, emotion, pain (dorsal cingulum), and episodic memory (parahippocampal cingulum), while clinical studies reveal cingulum abnormalities in numerous conditions, including schizophrenia, depression, post-traumatic stress disorder, obsessive compulsive disorder, autism spectrum disorder, Mild Cognitive Impairment, and Alzheimer’s disease. Understanding the seemingly diverse contributions of the cingulum will require better ways of isolating pathways within this highly complex tract.

扣带束是一个突出的白质束，它连接额叶、顶叶和内侧颞叶部位，同时也将皮质下核与扣带回连接起来。尽管具有明显的连续性，但扣带带的成分随着纤维加入和离开束而不断变化。为了帮助理解其复杂的结构，本综述首先对构成扣带束的多个连接进行了详细的比较描述。接下来，分析了扣带束损伤对大鼠、猴子和人类的影响。尽管造成广泛的解剖学断开，扣带束病变通常仅产生轻微的缺陷，突出了平行通路的重要性及其各种功能的分布性质。同时，非侵入性成像表明扣带束与执行控制、情绪、疼痛（背侧扣带回）和情景记忆（海马旁扣带回）有关，而临床研究表明扣带回在多种疾病中存在异常，包括精神分裂症、抑郁症、创伤后应激障碍、强迫症、自闭症谱系障碍、轻度认知障碍和阿尔茨海默病。了解扣带回看似不同的贡献将需要更好的方法来隔离这个高度复杂的区域内的通路。