A novel cobalt(0) alkyne complex assisted “capture and release” strategy for oligosaccharide rapid assembly†,Organic Chemistry Frontiers

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A novel cobalt(0) alkyne complex assisted “capture and release” strategy for oligosaccharide rapid assembly†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-05-17 00:00:00 , DOI: 10.1039/c8qo00324f
Yan-Bo Liu _{1,

2,

3} , Wang Yao _{1,

2,

3} , Shuai Meng _{1,

2,

3} , Xiang-Bao Meng _{1,

2,

3} , Zhong-Jun Li _{1,

2,

3} , Qing-Hua Lou _{1,

2,

3}

Affiliation

A chromatographic purification free rapid oligosaccharide synthetic strategy was developed. The intermediates were conveniently purified by a new process based on a “capture–release” strategy on a resin that involved the Co₂(CO)₆-PPh₂/alkyne complex and the oxidated de-complex reaction. This method avoids the redundant multi-step classical chromatographic purification protocol and has been proved to be efficient by the synthesis of linear and branched penta-mannosides.

中文翻译：

一种新型钴（0）炔烃配合物，可帮助“捕获和释放”寡糖快速组装策略†

开发了一种无色谱纯化的快速寡糖合成策略。通过基于“捕获-释放”策略的新工艺，在涉及Co ₂（CO）₆ -PPh ₂ /炔烃配合物和氧化解配合物的树脂上，通过新方法方便地纯化了中间体。该方法避免了多余的多步经典色谱纯化方法，并且通过线性和支化五甘露糖苷的合成已被证明是有效的。

更新日期：2018-05-17

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