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Development of sericin/alginate beads of ketoprofen using experimental design: Formulation and in vitro dissolution evaluation
Powder Technology ( IF 4.5 ) Pub Date : 2018-07-01 , DOI: 10.1016/j.powtec.2018.05.016
Emanuelle Dantas de Freitas , Paulo Cesar Pires Rosa , Meuris Gurgel Carlos da Silva , Melissa Gurgel Adeodato Vieira

Abstract The development of new forms of drugs from the current existing active principles is an alternative to the costly and time-consuming process of developing new ones. The blend of sericin and alginate has been proposed as a polymer matrix for the incorporation of ketoprofen as a modified formulation. An experimental design was performed by varying the initial amount of alginate and drug added. Incorporation efficiency, drug loading, and release time of 85% were applied as response variables. Drug loading was statistically affected by both independent variables and the highest value (40.25 ± 0.23%) was achieved for the lower amount of alginate and higher amount of ketoprofen initially added. The incorporation efficiency was statistically affected only by the amount of alginate and its higher values were reached by the smaller amount of alginate added. Time to release 85% was not affected by any of the independent variables, although the longer times were achieved for the greater amount of drug added. In general, the best particle produced was K3, produced with the lowest amount of alginate and higher amount of ketoprofen initially added. The characterization analyzes of SEM, FTIR, XRD, OM and TGA confirmed the incorporation of ketoprofen.

中文翻译:

使用实验设计开发酮洛芬丝胶/藻酸盐珠粒:配方和体外溶出度评价

摘要 从当前现有的活性成分开发新形式的药物是替代开发新药物的昂贵且耗时的过程。丝胶和藻酸盐的混合物已被提议作为聚合物基质,用于将酮洛芬作为改性制剂掺入。通过改变藻酸盐和药物添加的初始量来进行实验设计。掺入效率、载药量和 85% 的释放时间被用作响应变量。载药量在统计学上受两个自变量的影响,最高值 (40.25 ± 0.23%) 是最初添加的较低量的藻酸盐和较高量的酮洛芬实现的。掺入效率仅受藻酸盐量的统计影响,并且通过加入较少量的藻酸盐达到其较高值。释放时间 85% 不受任何自变量的影响,尽管添加的药物量越大,释放时间越长。一般而言,产生的最佳颗粒是 K3,最初添加的海藻酸盐量最低,酮洛芬的量更高。SEM、FTIR、XRD、OM 和 TGA 的表征分析证实了酮洛芬的掺入。
更新日期:2018-07-01
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