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New antioxidants from the culture broth of Hericium coralloides.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2018-Sep-01 , DOI: 10.1038/s41429-018-0067-6
Ji-Yul Kim , E-Eum Woo , In-Kyoung Lee , Bong-Sik Yun

In our effort to find antioxidants from the higher fungi, we isolated three new compounds (1-3) with a known compound, spirobenzofuran (4), from the culture broth of Hericium coralloides. Bioassay-guided fractionation led to the isolation of these compounds, and we determined the chemical structures through spectroscopic methods. These compounds exhibited antioxidant activity in the range of IC50 values of 29-66 μM in the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging assay.

中文翻译:

来自猴头菌的培养液中的新抗氧化剂。

为了从高等真菌中寻找抗氧化剂,我们从猴头菌的培养液中分离了三种新化合物(1-3)和一种已知化合物,螺苯并呋喃(4)。生物测定指导的分级分离导致这些化合物的分离,我们通过光谱方法确定了化学结构。这些化合物在2,2'-叠氮基双-(3-乙基苯并噻唑啉-6-磺酸)(ABTS)自由基清除试验中的IC 50值范围为29-66μM,表现出抗氧化活性。
更新日期:2018-05-17
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