A nickel-catalyzed conjunctive cross-coupling of non-conjugated alkenes, alkyl halides, and alkylzinc reagents is reported. Regioselectivity is controlled by chelation of a removable bidentate 8-aminoquinoline directing group. Under optimized conditions, a wide range of 1,2-dialkylated products can be accessed in moderate to excellent yields. To the best of our knowledge, this report represents the first example of three-component 1,2-dialkylation of non-conjugated alkenes to introduce differentiated alkyl fragments.

中文翻译：

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烯基羰基化合物的定向镍催化 1,2-二烷基化†

报道了非共轭烯烃、烷基卤化物和烷基锌试剂的镍催化联合交叉偶联。区域选择性由可去除的双齿 8-氨基喹啉导向基团的螯合控制。在优化条件下，可以以中等到优异的收率获得范围广泛的 1,2-二烷基化产品。据我们所知，这份报告代表了非共轭烯烃的三组分 1,2-二烷基化引入差异化烷基片段的第一个例子。