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Ag/AgBr-loaded mesoporous silica for rapid sterilization and promotion of wound healing†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-05-16 00:00:00 , DOI: 10.1039/c8bm00353j Chen Jin 1, 2, 3, 4, 5 , Xiangmei Liu 1, 2, 3, 4, 5 , Lei Tan 1, 2, 3, 4, 5 , Zhenduo Cui 4, 6, 7, 8 , Xianjin Yang 4, 6, 7, 8 , Yufeng Zheng 8, 9, 10, 11, 12 , Kelvin Wai Kwok Yeung 8, 13, 14, 15, 16 , Paul K. Chu 8, 17, 18, 19 , Shuilin Wu 1, 2, 3, 4, 5
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-05-16 00:00:00 , DOI: 10.1039/c8bm00353j Chen Jin 1, 2, 3, 4, 5 , Xiangmei Liu 1, 2, 3, 4, 5 , Lei Tan 1, 2, 3, 4, 5 , Zhenduo Cui 4, 6, 7, 8 , Xianjin Yang 4, 6, 7, 8 , Yufeng Zheng 8, 9, 10, 11, 12 , Kelvin Wai Kwok Yeung 8, 13, 14, 15, 16 , Paul K. Chu 8, 17, 18, 19 , Shuilin Wu 1, 2, 3, 4, 5
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Bacterial infection is a major concern during the wound healing process. Herein, Ag/AgBr-loaded mesoporous silica nanoparticles (Ag/AgBr/MSNs) are designed to harvest visible light for rapid sterilization and acceleration of wound healing. The Ag/AgBr nanostructure has remarkable photocatalysis ability due to the critical factor that it can generate electron–hole pairs easily after light absorption. This remarkable photocatalytic effect enhances the antibacterial activity by producing reactive oxygen species (ROS). The bacterial killing efficiency of Ag/AgBr/MSNs is 95.62% and 99.99% against Staphylococcus aureus and Escherichia coli, respectively, within 15 min under simulated solar light irradiation due to the generation of ROS. Furthermore, the composites can arrest the bacterial growth and damage the bacterial membrane through electrostatic interaction. The gradual release of Ag+ not only prevents bacterial infection with good long-term effectiveness but also stimulates the immune function to produce a large number of white blood cells and neutrophils, which favors the promotion of the wound healing process. This platform provides an effective strategy to prevent bacterial infection during wound healing.
中文翻译：
载有Ag / AgBr的中孔二氧化硅，可快速灭菌并促进伤口愈合†
细菌感染是伤口愈合过程中的主要问题。本文中，负载有Ag / AgBr的中孔二氧化硅纳米粒子（Ag / AgBr / MSNs）旨在收集可见光，以快速杀菌并加速伤口愈合。Ag / AgBr纳米结构具有重要的光催化能力，这归因于其在吸收光后很容易产生电子-空穴对的关键因素。这种显着的光催化作用通过产生活性氧（ROS）增强了抗菌活性。Ag / AgBr / MSNs对金黄色葡萄球菌和大肠杆菌的细菌杀灭效率分别为95.62％和99.99％由于ROS的产生，分别在模拟太阳光照射下15分钟内。此外，复合材料可通过静电相互作用阻止细菌生长并破坏细菌膜。Ag +的逐步释放不仅可以长期有效地预防细菌感染，而且还可以刺激免疫功能产生大量白细胞和中性粒细胞，有利于促进伤口愈合。该平台提供了一种有效的策略来防止伤口愈合过程中的细菌感染。
更新日期：2018-05-16
中文翻译：
载有Ag / AgBr的中孔二氧化硅，可快速灭菌并促进伤口愈合†
细菌感染是伤口愈合过程中的主要问题。本文中，负载有Ag / AgBr的中孔二氧化硅纳米粒子（Ag / AgBr / MSNs）旨在收集可见光，以快速杀菌并加速伤口愈合。Ag / AgBr纳米结构具有重要的光催化能力，这归因于其在吸收光后很容易产生电子-空穴对的关键因素。这种显着的光催化作用通过产生活性氧（ROS）增强了抗菌活性。Ag / AgBr / MSNs对金黄色葡萄球菌和大肠杆菌的细菌杀灭效率分别为95.62％和99.99％由于ROS的产生，分别在模拟太阳光照射下15分钟内。此外，复合材料可通过静电相互作用阻止细菌生长并破坏细菌膜。Ag +的逐步释放不仅可以长期有效地预防细菌感染，而且还可以刺激免疫功能产生大量白细胞和中性粒细胞，有利于促进伤口愈合。该平台提供了一种有效的策略来防止伤口愈合过程中的细菌感染。
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