Cooperativity Principles in Self-Assembled Nanomedicine,Chemical Reviews

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Cooperativity Principles in Self-Assembled Nanomedicine
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-04-25 00:00:00 , DOI: 10.1021/acs.chemrev.8b00195
Yang Li ₁ , Yiguang Wang _{1,

2} , Gang Huang ₁ , Jinming Gao ₁

Affiliation

Nanomedicine is a discipline that applies nanoscience and nanotechnology principles to the prevention, diagnosis, and treatment of human diseases. Self-assembly of molecular components is becoming a common strategy in the design and syntheses of nanomaterials for biomedical applications. In both natural and synthetic self-assembled nanostructures, molecular cooperativity is emerging as an important hallmark. In many cases, interplay of many types of noncovalent interactions leads to dynamic nanosystems with emergent properties where the whole is bigger than the sum of the parts. In this review, we provide a comprehensive analysis of the cooperativity principles in multiple self-assembled nanostructures. We discuss the molecular origin and quantitative modeling of cooperative behaviors. In selected systems, we describe the examples on how to leverage molecular cooperativity to design nanomedicine with improved diagnostic precision and therapeutic efficacy in medicine.

中文翻译：

自组装纳米医学中的协同原则

纳米医学是一门将纳米科学和纳米技术原理应用于人类疾病的预防，诊断和治疗的学科。在生物医学应用纳米材料的设计和合成中，分子成分的自组装正成为一种普遍的策略。在天然和合成的自组装纳米结构中，分子协同性都成为一个重要的标志。在许多情况下，许多类型的非共价相互作用会导致具有动态特性的动态纳米系统，其中整体大于各个部分的总和。在这篇综述中，我们对多种自组装纳米结构中的协同性原理进行了全面的分析。我们讨论了合作行为的分子起源和定量建模。在选定的系统中，

更新日期：2018-04-25

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