Protons as Versatile Reporters in Solid-State NMR Spectroscopy,Accounts of Chemical Research

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Protons as Versatile Reporters in Solid-State NMR Spectroscopy
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-05-15 00:00:00 , DOI: 10.1021/acs.accounts.8b00055
Suresh K. Vasa _{1,

2} , Petra Rovó _{1,

2} , Rasmus Linser _{1,

2}

Affiliation

Solid-state nuclear magnetic resonance (ssNMR) is a spectroscopic technique that is used for characterization of molecular properties in the solid phase at atomic resolution. In particular, using the approach of magic-angle spinning (MAS), ssNMR has seen widespread applications for topics ranging from material sciences to catalysis, metabolomics, and structural biology, where both isotropic and anisotropic parameters can be exploited for a detailed assessment of molecular properties. High-resolution detection of protons long represented the holy grail of the field. With its high natural abundance and high gyromagnetic ratio, ¹H has naturally been the most important nucleus type for the solution counterpart of NMR spectroscopy. In the solid state, similar benefits are obtained over detection of heteronuclei, however, a rocky road led to its success as their high gyromagnetic ratio has also been associated with various detrimental effects. Two exciting approaches have been developed in recent years that enable proton detection: After partial deuteration of the sample to reduce the proton spin density, the exploitation of protons could begin. Also, faster MAS, nowadays using tiny rotors with frequencies up to 130 kHz, has relieved the need for expensive deuteration. Apart from the sheer gain in sensitivity from choosing protons as the detection nucleus, the proton chemical shift and several other useful aspects of protons have revolutionized the field.

中文翻译：

质子作为固态NMR光谱中的多功能报告者

固态核磁共振（ssNMR）是一种光谱技术，用于以原子分辨率表征固相中的分子性质。尤其是，使用魔术角旋转（MAS）的方法，ssNMR已广泛应用于从材料科学到催化，代谢组学和结构生物学的主题，其中各向同性和各向异性参数均可用于分子的详细评估特性。质子的高分辨率检测长期以来就是该领域的圣杯。天然丰度高，旋磁比高，¹对于NMR光谱的溶液对应物，H自然是最重要的原子核类型。在固态下，通过检测杂核可以获得类似的好处，但是，由于其高的回磁比还与各种有害作用相关，因此在多岩石的道路上取得了成功。近年来，已经开发出了两种令人兴奋的方法来实现质子检测：在对样品进行部分氘化以降低质子自旋密度之后，可以开始利用质子了。而且，如今使用频率高达130 kHz的微型转子的更快的MAS消除了对昂贵的氘代的需求。除了通过选择质子作为检测核而获得的灵敏性之外，质子的化学位移和质子的其他几个有用方面也革新了该领域。

更新日期：2018-05-15

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