Melanins are pigment molecules that determine the skin, eye, and hair color of the human subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide epidermal protection from various stimuli, such as harmful ultraviolet radiation, through the complex process called melanogenesis. However, serious dermatological problems occur when there is excessive production of melanin in different parts of the human body. These include freckles, melasma, senile lentigo, pigmented acne scars, and cancer. Therefore, controlling the production of melanin is an important approach for the treatment of pigmentation related disorderes. In this Perspective, we focus on the inhibitors of melanogenesis that directly/indirectly target a key enzyme tyrosinase as well as its associated signaling pathways.

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黑色素生成的抑制剂：最新评论

黑色素是颜料分子，可决定人体的皮肤，眼睛和头发的颜色，数量和分布。黑色素细胞通过称为黑色素生成的复杂过程，合成黑色素并为各种刺激（例如有害的紫外线）提供表皮保护。但是，当人体不同部位产生过多的黑色素时，就会出现严重的皮肤病学问题。这些包括雀斑，黄褐斑，老年性扁豆，色素性痤疮疤痕和癌症。因此，控制黑色素的产生是治疗色素沉着相关疾病的重要方法。在此观点中，我们关注直接/间接靶向关键酶酪氨酸酶及其相关信号通路的黑色素生成抑制剂。