In the present work, a crystallization-induced strontium-bioactive material, with a composition similar to Bioglass 45S5 system, was obtained using a sol–gel-assisted microwave method with nanorod morphologies of 30–80 nm in size. The effect of crystallization induced in the glass network, and its influence on the bioactivity and mechanical properties of bone and dentin regeneration, were the main novel findings of this work. Rietveld analysis of X-ray diffraction spectra showed the best fit with sodium (combeite, Na₂Ca₂Si₃O₉) and calcium (clinophosinaite, Ca₂Na₆O₁₄P₂Si₂; calcium strontium silicate, Ca_1.5O₄SiSr_0.5; and calcium carbonate, CaCO₃) enriched crystal systems. Multinuclear solid-state NMR studies provided detailed atomistic insight into the presence of crystalline mineral phases in the bioactive material. The dentin matrix and antibacterial studies showed good results for 5% strontium-substituted calcium compared with basic 45S5 composition due to its smaller particle size (30 nm), which suggested applications to dentin regeneration. Simulation studies have been demonstrated with clinophosinaite crystal data from the XRD spectra, with the glycoprotein salivary metabolites also showing that 5% strontium-substituted calcium has a higher binding affinity for the salivary compound, which is suitable for dentin regeneration applications. In vitro apatite formation studies showed that this material is suitable for bone regeneration applications.

中文翻译：

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高活性晶相嵌入锶生物活性纳米棒，用于多峰生物活性应用†

在目前的工作中，使用溶胶-凝胶辅助微波法以30-80 nm的纳米棒形态获得了结晶诱导的锶生物活性材料，其成分类似于Bioglass 45S5系统。在玻璃网络中诱导的结晶作用及其对骨骼的生物活性和力学性能以及牙本质再生的影响，是这项工作的主要新发现。X射线衍射光谱的Rietveld分析表明，钠（钙镁铝石，Na ₂ Ca ₂ Si ₃ O ₉）和钙（斜硅锰矿，Ca ₂ Na ₆ O ₁₄ P ₂ Si ₂钙；硅酸钙锶，钙）最合适_1.5 O ₄ SiSr _0.5 ; 和碳酸钙，CaCO ₃）富集的晶体系统。多核固态NMR研究提供了生物活性材料中晶体矿物相的存在的详细原子学见解。牙本质基质和抗菌素研究表明，与碱性45S5组合物相比，5％锶取代的钙具有更好的效果，因为其粒径较小（30 nm），这提示其在牙本质再生中的应用。通过XRD光谱中的斜硅次膦酸盐晶体数据证明了模拟研究，糖蛋白唾液代谢产物还显示5％锶取代的钙对唾液化合物具有更高的结合亲和力，适用于牙本质再生应用。体外磷灰石形成研究表明该材料适用于骨再生应用。