Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles,Small Methods

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Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles
Small Methods ( IF 10.7 ) Pub Date : 2018-05-07 , DOI: 10.1002/smtd.201800007
Eduardo Guisasola _{1,

2,

3} , Alejandro Baeza _{1,

2} , Laura Asín _{2,

4} , Jesús M. de la Fuente _{2,

4} , María Vallet-Regí _{1,

2}

Affiliation

Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the use of responsive nanomaterials are not different, and researchers have carried out many attempts to overcome their drawbacks due to the valuable potential of these techniques. Here, an overview is presented of nanodevices based on magnetic‐ and photoresponsive nanocrystals that respond to magnetic fields and/or near‐infrared stimuli for cancer therapies. Special attention is given to the synergic effect that can be achieved with nanoscale heating in combination with chemotherapy through drug‐delivery devices to effectively kill cancer cells. In this way, the nanoparticles act as heating sources or “hot spots,” which can trigger cellular responses in the absence of a global temperature rise, making the tumor cells more sensitive to chemotherapeutics. The fabrication of optical and magnetic drug‐delivery devices, the heating mechanisms, and their applications in tumor treatment are also summarized.

中文翻译：

通过药物输送装置在纳米级加热：纳米粒子在癌症治疗中的制备和协同效应

用于癌症治疗的纳米载体已经得到了广泛的研究，但是为了实现其安全应用，仍然需要解决一些研究。在该领域中，通过使用响应性纳米材料介导的高温疗法没有什么不同，并且由于这些技术的宝贵潜力，研究人员已进行了许多尝试来克服它们的缺点。在此，将对基于磁性和光响应纳米晶体的纳米设备进行概述，这些纳米晶体可对磁场和/或近红外刺激物做出响应，以用于癌症治疗。特别要注意的是，纳米加热结合药物递送装置与化学疗法相结合可以有效杀死癌细胞的协同作用。这样，纳米颗粒就可以充当热源或“热点”，在没有整体温度升高的情况下可以触发细胞反应，从而使肿瘤细胞对化学疗法更加敏感。还总结了光学和磁性药物递送装置的制造，加热机制及其在肿瘤治疗中的应用。

更新日期：2018-05-07

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