Palladium‐Catalyzed ortho C−H Arylation of Benzaldehydes Using ortho‐Sulfinyl Aniline as Transient Auxiliary,Chemistry - An Asian Journal

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Palladium‐Catalyzed ortho C−H Arylation of Benzaldehydes Using ortho‐Sulfinyl Aniline as Transient Auxiliary
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-06-13 , DOI: 10.1002/asia.201800581
Delong Mu ₁ , Gang He ₁ , Gong Chen _{1,

2}

Affiliation

A Pd^II‐catalyzed ortho‐(Csp²)–H arylation reaction of benzaldehydes using a catalytic amount of 2‐(methylsulfinyl)aniline as transient auxiliary was developed. This reaction is compatible with a broad range of benzaldehyde and aryl iodide substrates. Compared with other related reaction systems, an excellent regioselectivity for ortho‐C(sp²)−H bonds over benzylic C(sp³)−H bonds was obtained for ortho‐alkyl‐benzaldehyde substrates.

中文翻译：

邻亚磺酰基苯胺作为过渡助剂的钯催化苯甲醛的邻位CHH芳基化

利用催化量的2-（甲基亚磺酰基）苯胺作为过渡助剂，进行了Pd ^II催化的苯甲醛的邻-（Csp ²）-H芳基化反应。该反应与广泛的苯甲醛和碘代芳基底物相容。与其他相关的反应系统相比，对于邻烷基苯甲醛底物，对邻-C（sp ²）-H键具有优于苄基C（sp ³）-H键的区域选择性。

更新日期：2018-06-13

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