Biocompatible alkyl cyanoacrylates and their derivatives as bio-adhesives,Biomaterials Science

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Biocompatible alkyl cyanoacrylates and their derivatives as bio-adhesives
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-05-15 00:00:00 , DOI: 10.1039/c8bm00312b
Jay M. Korde _{1,

2,

3,

4,

5} , Balasubramanian Kandasubramanian _{1,

2,

3,

4,

5}

Affiliation

Cyanoacrylate adhesives and their homologues have elicited interest over the past few decades owing to their applications in the biomedical sector, extending from tissue adhesives to scaffolds to implants to dental material and adhesives, because of their inherent biocompatibility and ability to polymerize solely with moisture, thanks to which they adhere to any substrate containing moisture such as the skin. The ability to tailor formulations of alkyl cyanoacrylate to form derivative compounds to meet application requirements along with their biodegradability in conjunction with their inherent biocompatibility make them highly sought after candidates in the biomedical sector. There has been extensive exploration of cyanoacrylate adhesives and their homologue systems in biomedical applications, but no consolidated literature of the vast data is available. The ability of cyanoacrylate adhesives to cure at low temperatures and without the need for any hardener, which is attributed to the high-strength bonding interaction between two non-amalgamating substrates, with their ease of dispersion and self-curing, avoids the curtailing of the effective utilization of such adhesives in biomedical engineering applications as bio glues for amalgamating tissues, implants, scaffolds etc. This article consolidates copious work on cyanoacrylate adhesives and their derived systems which are functional in versatile biomedical engineering applications such as bio glues, dental material and adhesives and other potential applications.

中文翻译：

生物相容性氰基丙烯酸烷基酯及其衍生物

由于氰基丙烯酸酯粘合剂及其同系物在生物医学领域的应用，在过去的几十年中引起了人们的兴趣，由于它们固有的生物相容性和仅与水分聚合的能力，因此从组织粘合剂到支架，再到植入物再到牙科材料和粘合剂，都受到了人们的关注。它们粘附到任何含有水分的基质（例如皮肤）上。定制氰基丙烯酸烷基酯以形成衍生物化合物以满足应用要求的能力，以及它们的生物降解性和固有的生物相容性，使其成为生物医学领域备受追捧的候选者。氰基丙烯酸酯胶粘剂及其同系物体系在生物医学应用中进行了广泛的探索，但是尚无有关大量数据的综合文献。氰基丙烯酸酯胶粘剂在低温下无需任何固化剂的固化能力，这归因于两个非汞齐化基材之间的高强度键合相互作用，易于分散和自固化，从而避免了氰基丙烯酸酯胶粘剂的缩减。在生物医学工程应用中有效利用此类粘合剂，例如用于融合组织，植入物，支架的生物胶等。本文巩固了在氰基丙烯酸酯胶粘剂及其衍生体系方面的大量工作，这些胶粘剂在通用生物医学工程应用中具有功能，例如生物胶，牙科材料和胶粘剂以及其他潜在应用。

更新日期：2018-05-15

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