Structural differences in pathological and functional amyloid fibrils have been investigated by Raman microspectroscopy. Second-derivative analyses of amide-I and amide-III bands distinguish parallel in-register β-sheets from a β-solenoid. Further, spatially resolved Raman spectra reveal molecular heterogeneity in amyloid structures.

中文翻译：

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淀粉样结构的拉曼指纹†

通过拉曼光谱研究了病理和功能淀粉样蛋白原纤维的结构差异。酰胺-I和酰胺-III谱带的二阶导数分析将平行的配准β-折叠片与β-类电磁体区分开来。此外，空间分辨的拉曼光谱揭示了淀粉样蛋白结构中的分子异质性。