Aryl halides are an indispensably important class of compounds owing to their role as precursors in the synthesis of organometallic reagents and nucleophilic substitution reactions. In addition, with the advent of cross‐coupling chemistry, the importance of aryl halides has increased tremendously, and they are therefore classified as the core building blocks in organic synthesis. With the recent advances in the area of transition‐metal‐catalyzed C−H functionalization, metal‐catalyzed C−H halogenation has emerged as a modern tool in organic synthesis. This focus review highlights the significant developments in the area of directed C−H halogenation reactions, particularly in the last two years.

中文翻译：

---

过渡金属催化的位点选择性CH卤化反应

由于芳族卤化物作为前体在有机金属试剂的合成和亲核取代反应中的作用，因此芳族卤化物是必不可少的一类化合物。此外，随着交叉偶联化学的出现，芳基卤化物的重要性已大大提高，因此，它们被分类为有机合成的核心组成部分。随着过渡金属催化CH官能化领域的最新进展，金属催化CH卤化已成为有机合成中的现代工具。这次重点回顾强调了直接CH卤代反应领域的重大进展，特别是在过去的两年中。