Controlled Delivery of Insulin Using Rapidly Separating Microneedles Fabricated from Genipin‐Crosslinked Gelatin,Macromolecular Rapid Communications

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Controlled Delivery of Insulin Using Rapidly Separating Microneedles Fabricated from Genipin‐Crosslinked Gelatin
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2018-05-02 , DOI: 10.1002/marc.201800075
Bo Zhi Chen ₁ , Mohammad Ashfaq ₁ , Dan Dan Zhu ₁ , Xiao Peng Zhang ₁ , Xin Dong Guo ₁

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Rapidly separating genepin‐crosslinked gelatin (RS‐GC) microneedles (MNs) mounted on the polyvinyl alcohol (PVA)‐coated polylactic acid (PLA) MNs (RS‐PGC‐MNs) are fabricated, in which GC‐MNs deliver insulin within the skin and the PLA supporting array is easily separated by the dissolution of the PVA layer. The release of insulin is controlled by utilizing the virtue of genipin as a crosslinking agent for producing biocompatible GC‐MNs. The degree of crosslinking enhances the mechanical strength as well as humidity resistance. The in vitro and in vivo insulin release tests show significant changes in the release rates in the RS‐PGC‐MNs with different crosslinking degree. The hypoglycemic effect in diabetic mice demonstrate that the higher crosslinking GC‐MNs result in characteristic controlled insulin release compared with other treatments and prolonged effectiveness of the RS‐PGC‐MNs. The proposed RS‐PGC‐MNs is a promising device for effective use as a noninvasive and painless controlled insulin delivery system.

中文翻译：

用快速分离的Genipin交联明胶制成的微针控制胰岛素的递送

快速分离安装在聚乙烯醇（PVA）涂层的聚乳酸（PLA）MN（RS-PGC-MNs）上的基因针交联明胶（RS-GC）微针（MNs），其中GC-MNs将胰岛素输送至皮肤和PLA支撑阵列很容易通过PVA层的溶解而分离。利用genipin作为交联剂来生产生物相容性GC-MNs，可以控制胰岛素的释放。交联度提高了机械强度以及耐湿性。体外和体内胰岛素释放测试表明，具有不同交联度的RS-PGC-MNs的释放速率发生了显着变化。糖尿病小鼠的降血糖作用表明，与其他治疗方法相比，较高的交联GC-MNs具有特征性的受控胰岛素释放，并具有更长的RS-PGC-MNs有效性。拟议中的RS‐PGC‐MN是有效用作无创且无痛控制的胰岛素输送系统的有前途的设备。

更新日期：2018-05-02

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