A facile method for the synthesis of trifluoromethylthio-/chloro-homoallylic alcohols from methylenecyclopropanes†,Organic Chemistry Frontiers

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A facile method for the synthesis of trifluoromethylthio-/chloro-homoallylic alcohols from methylenecyclopropanes†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-05-14 00:00:00 , DOI: 10.1039/c8qo00386f
Mintao Chen _{1,

2,

3,

4,

5} , Yin Wei _{1,

2,

3,

4,

5} , Min Shi _{1,

2,

3,

4,

5}

Affiliation

A facile method for the synthesis of trifluoromethylthio-homoallylic alcohols from methylenecyclopropanes (MCPs) has been achieved with the application of (PhSO₂)₂NSCF₃ in N,N-dimethyl formamide (DMF). It has been proved that DMF plays a role both as a solvent and a reagent. Meanwhile, we find that (PhSO₂)₂NCl is also an active reagent to afford chloro-homoallylic alcohols in the same way as (PhSO₂)₂NSCF₃, and it is very convenient to convert the product to the corresponding amido- or bromo-substituted compounds.

中文翻译：

从亚甲基环trifluoromethylthio- /氯高烯丙醇的合成一种简便方法†

通过将（PhSO ₂）₂ NSCF ₃应用于N，N-二甲基甲酰胺（DMF），已经实现了一种由亚甲基环丙烷（MCPs）合成三氟甲硫基-均烯丙基醇的简便方法。已经证明DMF既充当溶剂又充当试剂。同时，我们发现（PhSO ₂）₂ NCl也是与（PhSO ₂）₂ NSCF ₃相同的提供氯均丙醇的活性试剂，将产物转化为相应的酰胺基或酰胺基非常方便。溴取代的化合物。

更新日期：2018-05-14

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