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A facile method for the synthesis of trifluoromethylthio-/chloro-homoallylic alcohols from methylenecyclopropanes†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-05-14 00:00:00 , DOI: 10.1039/c8qo00386f
Mintao Chen 1, 2, 3, 4, 5 , Yin Wei 1, 2, 3, 4, 5 , Min Shi 1, 2, 3, 4, 5
Affiliation  

A facile method for the synthesis of trifluoromethylthio-homoallylic alcohols from methylenecyclopropanes (MCPs) has been achieved with the application of (PhSO2)2NSCF3 in N,N-dimethyl formamide (DMF). It has been proved that DMF plays a role both as a solvent and a reagent. Meanwhile, we find that (PhSO2)2NCl is also an active reagent to afford chloro-homoallylic alcohols in the same way as (PhSO2)2NSCF3, and it is very convenient to convert the product to the corresponding amido- or bromo-substituted compounds.

中文翻译:

从亚甲基环trifluoromethylthio- /氯高烯丙醇的合成一种简便方法

通过将(PhSO 22 NSCF 3应用于NN-二甲基甲酰胺(DMF),已经实现了一种由亚甲基环丙烷(MCPs)合成三氟甲硫基-均烯丙基醇的简便方法。已经证明DMF既充当溶剂又充当试剂。同时,我们发现(PhSO 22 NCl也是与(PhSO 22 NSCF 3相同的提供氯均丙醇的活性试剂,将产物转化为相应的酰胺基或酰胺基非常方便。溴取代的化合物。
更新日期:2018-05-14
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