Utilizing 1,2-diaminocyclopropane-1,2-dicarboxylic acid (DACDC) as a tetrafunctional peptide linker is proposed and discussed on the basis of the ab initio second-order Møller-Plesset and density functional theory (DFT) theoretical studies. It is demonstrated that the DACDC molecule may form four peptide bonds with natural amino acids such as alanine and, as a consequence, two peptide chains might be connected to each other by the DACDC unit which in turn reveals the ability of DACDC to act as a new type of peptide linker – peptide clasp.

中文翻译：

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功能化的ACC分子可作为有效的肽扣

在从头算二阶Møller-Plesset和密度泛函理论（DFT）的理论研究的基础上，提出并讨论了使用1,2-二氨基环丙烷-1，2-二羧酸（DACDC）作为四官能肽接头。结果表明，DACDC分子可与天然氨基酸（如丙氨酸）形成四个肽键，因此，两个肽链可能会通过DACDC单元相互连接，这又揭示了DACDC的功能。新型肽接头–肽扣。