当前位置: X-MOL 学术Biomacromolecules › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Luminescent Gold Nanocluster-Decorated Polymeric Hybrid Particles with Assembly-Induced Emission.
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-05-23 , DOI: 10.1021/acs.biomac.8b00414
Mathew Hembury 1 , Nataliia Beztsinna 1 , Hamed Asadi 1 , Joep B van den Dikkenberg 1 , Johannes D Meeldijk 2 , Wim E Hennink 1 , Tina Vermonden 1
Affiliation  

Ultrasmall gold atom clusters (<2 nm in diameter) or gold nanoclusters exhibit emergent photonic properties (near-infrared absorption and emission) compared to larger plasmonic gold particles because of the significant quantization of their conduction band. Although single gold nanocluster properties and applications are being increasingly investigated, little is still known about their behavior and properties when assembled into suprastructures, and even fewer studies are investigating their use for biomedical applications. Here, a simple synthetic pathway combines gold nanoclusters with thermosensitive diblock copolymers of poly(ethylene glycol) (PEG) and poly( N-isopropylacrylamide) (PNIPAm) to form a new class of gold-polymer, micelle-forming, hybrid nanoparticle. The nanohybrids' design is uniquely centered on enabling the temperature-dependent self-assembly of gold nanoclusters into the hydrophobic cores of micelles. This nonbulk assembly not only preserves but also enhances the attractive near-infrared photonics of the gold nanoclusters by significantly increasing their native fluorescent signal. In parallel to the fundamental insights into gold nanocluster ordering and assembly, the gold-polymer nanohybrids also demonstrated great potential as fluorescent live-imaging probes in vitro. This innovative material design based on the temperature-dependent, self-assembly of gold nanoclusters within a polymeric micelle's core shows great promise toward bioassays, nanosensors, and nanomedicine.

中文翻译:

发光金纳米簇修饰的聚合物杂化颗粒,具有组装诱导发射。

与较大的等离激元金颗粒相比,超小金原子簇(直径<2 nm)或金纳米团簇显示出新兴的光子特性(近红外吸收和发射),因为它们的导带得到了显着的量化。尽管越来越多地研究单一金纳米簇的性质和应用,但对于组装成超结构的行为和性质仍知之甚少,甚至很少有研究研究其在生物医学应用中的用途。在这里,一条简单的合成途径将金纳米团簇与聚(乙二醇)(PEG)和聚(N-异丙基丙烯酰胺)(PNIPAm)的热敏二嵌段共聚物结合在一起,形成一类新的金聚合物,形成胶束的杂化纳米颗粒。纳米杂种 设计的唯一重点是使金纳米团簇能够根据温度自动组装到胶束的疏水核中。这种非整体组装不仅可以显着增加金纳米团簇的天然荧光信号,而且可以保留金纳米团簇,还可以增强其吸引力,并增强近红外光子学的吸引力。除了对金纳米团簇有序和组装的基本见解外,金聚合物纳米杂合物还显示出作为荧光实时成像探针的巨大潜力。这种创新的材料设计基于聚合物胶束核心中金纳米团簇的温度依赖性自组装,对生物测定,纳米传感器和纳米药物具有广阔的前景。这种非整体组装不仅可以显着增加金纳米团簇的天然荧光信号,而且可以保留金纳米团簇,还可以增强其吸引力,并增强近红外光子学的吸引力。除了对金纳米团簇有序和组装的基本见解外,金聚合物纳米杂合物还显示出作为荧光实时成像探针的巨大潜力。这种创新的材料设计基于聚合物胶束核心中金纳米团簇的温度依赖性自组装,对生物测定,纳米传感器和纳米药物具有广阔的前景。这种非整体组装不仅可以显着增加金纳米团簇的天然荧光信号,而且可以保留金纳米团簇,还可以增强它们的近红外光子学。除了对金纳米团簇有序和组装的基本见解外,金聚合物纳米杂合物还显示出作为荧光实时成像探针的巨大潜力。这种创新的材料设计基于聚合物胶束核心中金纳米团簇的温度依赖性自组装,对生物测定,纳米传感器和纳米药物具有广阔的前景。金聚合物纳米杂交体在体外作为荧光实时成像探针也显示出巨大的潜力。这种创新的材料设计基于聚合物胶束核心中金纳米团簇的温度依赖性自组装,对生物测定,纳米传感器和纳米药物具有广阔的前景。金聚合物纳米杂交体在体外作为荧光实时成像探针也显示出巨大的潜力。这种创新的材料设计基于聚合物胶束核心中金纳米团簇的温度依赖性自组装,对生物测定,纳米传感器和纳米药物具有广阔的前景。
更新日期:2018-05-11
down
wechat
bug