Although metal-organic frameworks (MOFs) are more commonly known for their applications in storage and separations, they are less well known for being employed as a highly efficient cell-free system to support enzymatic reactions. In this issue ofChem, Li et al. report a strategy for expanding the pore apertures of a series of Zr-based MOFs through the precise control of torsional angles associated with the linkers. The designed porous structure provides many benefits, including substrate and product diffusion, enzyme and coenzyme accessibility, and controlled encapsulation of the enzymes. As a proof of concept, lactate dehydrogenase is encapsulated and shown to work successfully as a cell-free biosynthetic catalytic system. In their catalyst piece, Bradley Olsen and Bryan Boudouris discuss how a better understanding of the fundamentals of long-established types of polymeric materials can spark innovation and lead to new breakthroughs in polymer science.

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尽管金属有机框架（MOF）因其在存储和分离中的应用而广为人知，但由于用作支持酶促反应的高效无细胞系统而鲜为人知。在《化学》杂志的这一期中，Li等人。报告了通过精确控制与连接子相关的扭转角来扩大一系列基于Zr的MOF的孔径的策略。设计的多孔结构具有许多优势，包括底物和产物的扩散，酶和辅酶的可及性以及酶的受控包封。作为概念的证明，乳酸脱氢酶被封装起来，并被证明可以作为无细胞的生物合成催化系统成功地发挥作用。在他们的催化剂片中，