Fast Degradable Polycaprolactone for Drug Delivery,Biomacromolecules

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Fast Degradable Polycaprolactone for Drug Delivery
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-05-09 00:00:00 , DOI: 10.1021/acs.biomac.8b00266
Seo Hee Chang ₁ , Hyun Jung Lee ₁ , Sohee Park ₁ , Yelin Kim ₁ , Byeongmoon Jeong ₁

Affiliation

Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide-co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a fast degradable PCL while maintaining its crystalline properties and low melting point of PCL. The in vivo application of the paclitaxel-loaded PCL-OX microspheres provided a steady plasma drug concentration of 6–9 μg/mL over 28 days, similar to that of the PLGA microspheres. Both PCL and PLGA microspheres were completely cleared two months after in vivo implantation. The PCL-OX microspheres showed a similar tissue compatibility to that of PLGA microspheres in the subcutaneous layer of rats. These findings suggest that PCL-OX is a useful biomaterial that solves the slow degradation problems of PCL and, thus, may find uses in other biomedical applications as an alternative to PLGA.

中文翻译：

快速可降解聚己内酯用于药物输送

聚己内酯（PCL）是很久以前报道的。然而，与聚丙交酯共聚物相比，其生物医学应用尚未得到广泛研究。-乙交酯（PLGA），因为其降解速度太慢。在这里，我们报道了一种草酸酯连接的低聚己内酯多嵌段共聚物（PCL-OX），它是一种可快速降解的PCL，同时保持了其结晶特性和PCL的低熔点。载有紫杉醇的PCL-OX微球的体内应用可在28天之内提供稳定的血浆药物浓度6–9μg/ mL，与PLGA微球相似。体内植入两个月后，PCL和PLGA微球均被完全清除。PCL-OX微球在大鼠皮下层显示出与PLGA微球相似的组织相容性。这些发现表明，PCL-OX是一种有用的生物材料，可以解决PCL的缓慢降解问题，因此，可以替代PLGA在其他生物医学应用中找到用途。

更新日期：2018-05-09

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