Structures and Biological Evaluation of Monoterpenoid Glycosides from the Roots of Paeonia lactiflora,Journal of Natural Products

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Structures and Biological Evaluation of Monoterpenoid Glycosides from the Roots of Paeonia lactiflora
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-05-09 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00087
Rui Li ₁ , Jing-Fang Zhang ₁ , Yu-Zhuo Wu ₁ , Yan-Cheng Li ₁ , Gui-Yang Xia ₁ , Ling-Yan Wang ₁ , Bo-Lin Qiu ₁ , Min Ma ₁ , Sheng Lin ₁

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Fractionation of an aqueous extract of the air-dried roots of a traditional Chinese medicinal plant, Paeonia lactiflora, yielded the new monoterpenoid glycosides 1–10. Their structures were assigned via spectroscopic techniques, and the absolute configurations of 1, 4–6, and 8 were verified via chemical methods, specific rotation, and electronic circular dichroism data. Compounds 1–4 are rare compared to the reported cage-like paeoniflorin derivatives; that is, they comprised two monoterpenoidal moieties. In the in vitro assay, compounds 5, 8, and 9 showed weak inhibitions against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, with IC₅₀ values of 64.8, 60.1, and 97.5 μM, respectively.

更新日期：2018-05-09

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