A highly water-soluble triblock conjugated polymer for in vivo NIR-II imaging and photothermal therapy of cancer†,Polymer Chemistry

当前位置： X-MOL 学术 › Polym. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A highly water-soluble triblock conjugated polymer for in vivo NIR-II imaging and photothermal therapy of cancer†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-05-09 00:00:00 , DOI: 10.1039/c8py00215k
Xiaomei Lu _{1,

2,

3,

4,

5} , Pengcheng Yuan _{2,

6,

7,

8,

9} , Wansu Zhang _{2,

6,

7,

8,

9} , Qi Wu _{1,

2,

3,

4,

5} , Xiaoxiao Wang _{1,

2,

3,

4,

5} , Meng Zhao _{1,

2,

3,

4,

5} , Pengfei Sun _{2,

6,

7,

8,

9} , Wei Huang _{5,

10,

11,

12} , Quli Fan _{2,

6,

7,

8,

9}

Affiliation

Applications of the second near infrared (NIR) optical window (NIR-II, 1000–1700 nm) have received increasing attention with respect to reduced scattering and negligible auto-fluorescence, thus achieving a high signal-to-background ratio for pinpointing tumors compared with NIR-I imaging. Conjugated polymers have been applied in NIR-II imaging for their advantages, such as high molar extinction coefficient, wide emission wavelength, and ease of preparation. However, currently available conjugated polymer NIR-II agents suffer from a lack of water solubility. Hence, a highly water-soluble triblock conjugated polymer (POEGMA-b-PDPP-b-POEGMA) based on diketopyrrolopyrrole was successfully prepared with a high yield. The NIR-II imaging depth of the conjugated polymer was ∼7 mm, which is far beyond conventional NIR-I agents. Furthermore, the fluorescence quantum yield (QY) of POEGMA-b-PDPP-b-POEGMA reached up to 1.0%, which is higher than most reported NIR-II probes. This novel NIR-II conjugated polymer shows improved solubility (>10 mg mL⁻¹) and greater dispersion in aqueous solution compared to those conventional conjugated polymers, due to the introduction of the water-soluble polymer POEGMA. With the help of high emission (>1000 nm), POEGMA-b-PDPP-b-POEGMA could efficiently realize the highly penetrable NIR-II imaging of tumors. In addition, POEGMA-b-PDPP-b-POEGMA could be a promising photothermal therapy agent to ablate tumors due to its high photothermal conversion efficiency (52%).

中文翻译：

用于癌症的体内NIR-II成像和光热疗法的高度水溶性三嵌段共轭聚合物†

第二近红外（NIR）光学窗口（NIR-II，1000-1700 nm）的应用在减少散射和可忽略的自发荧光方面引起了越来越多的关注，从而实现了较高的信噪比，可精确定位肿瘤使用NIR-I成像。共轭聚合物由于其优点，例如高的消光系数，较宽的发射波长和易于制备而被用于NIR-II成像。然而，当前可用的共轭聚合物NIR-II试剂缺乏水溶性。因此，高度水溶性的三嵌段共轭聚合物（POEGMA- b -PDPP- b以高产率成功制备了基于二酮吡咯并吡咯的-POEGMA）。共轭聚合物的NIR-II成像深度约为7毫米，远远超出了传统的NIR-I试剂。此外，POEGMA- b -PDPP- b -POEGMA的荧光量子产率（QY）高达1.0％，高于大多数报道的NIR-II探针。由于引入了水溶性聚合物POEGMA，与那些常规的共轭聚合物相比，这种新颖的NIR-II共轭聚合物显示出改善的溶解度（> 10 mg mL ^-1）和在水溶液中的更大分散性。借助高发射（> 1000 nm），POEGMA- b -PDPP- b-POEGMA可以有效地实现肿瘤的高穿透性NIR-II成像。此外，POEGMA- b -PDPP- b -POEGMA因其高的光热转化效率（52％）而有望成为消融肿瘤的有前途的光热治疗剂。

更新日期：2018-05-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11