A series of Ni(II), Zn(II) and Cd(II) complexes with the Schiff base derived from the condensation 1:1 from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil (6-amino-1,3-dimethyl-5-[(pyridin-2-ylmethylidene)-amino]pyrimidine-2,4(1H,3H)-dione, DAAUPic) were synthesized and subsequently characterized by means of elemental analysis, FT-IR, NMR and nine of them by X-ray diffraction. Except the [Zn(μ-O,O′-AcO)(N⁵,N⁶,N^1F-DAAUPicH_–1)]₂ and [Cd(O,O′-NO₃)(μ-O⁴,(N⁵,N⁶,N^1F)-DAAUPicH₋₁)(H₂O)]₂·2H₂O dimers and the [Cd(μ-S,N-SCN)(N⁵,N⁶,N^1F-DAAUPicH₋₁)]_n chain-like polymer, all of them display monomeric molecular structures. The anticancer activity of compounds was also explored studying their effects on renin-angiotensin system (RAS)-regulating aminopeptidases on estrogen-dependent and triple negative breast cancer cell lines. At the concentrations used, some of the complexes showed different effects on (RAS) peptidases, which support the idea that their effects on cell growth/proliferation could be related to autocrine/paracrine regulatory functions of their corresponding peptide substrates.

一系列Ni（II），Zn（II）和Cd（II）与席夫碱的配合物，席夫碱是由吡啶-2-甲醛和5,6-二氨基-1,3-二甲基尿嘧啶（6-合成了氨基-1,3-二甲基-5-[（吡啶-2-基亚甲基）-氨基]嘧啶-2,4（1 H，3 H）-二酮，DAAUPic），随后通过元素分析（FT）进行了表征-IR，NMR，以及其中的9个通过X射线衍射分析。除了[锌（μ- ø，O' -AcO）（Ñ ⁵，Ñ ⁶，Ñ ^1F -DAAUPicH _-1）] ₂和[CD（ø，O' -NO ₃）（μ- Ò ⁴，（N ⁵，N ⁶，N ^1F）-DAAUPicH _-1）（H ₂ O）] ₂ ·2H ₂ O二聚体和[Cd（μ- S，N -SCN）（N ⁵，N ⁶，N ^1F -DAAUPicH _-1）] _n链状聚合物，它们都显示单体分子结构。还研究了该化合物的抗癌活性，研究了它们对雌激素依赖性和三阴性乳腺癌细胞系中调节肾素-血管紧张素系统（RAS）的氨基肽酶的作用。在所使用的浓度下，某些复合物对（RAS）肽酶表现出不同的作用，这支持以下观点：它们对细胞生长/增殖的作用可能与其相应肽底物的自分泌/旁分泌调节功能有关。