Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila.,Journal of Natural Products

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Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-05-08 , DOI: 10.1021/acs.jnatprod.8b00135
Yongle Du ₁ , Ana L Valenciano ₂ , Michael Goetz ₃ , Maria B Cassera ₂ , David G I Kingston ₁

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An extract of Petradoria pumila from the Natural Products Discovery Institute was found to have moderate antiplasmodial activity, with an IC50 value between 5 and 10 μg/mL. The four new diterpenoids petradoriolides A-D (1-4), the new benzotropolone petradoriolone (5), and the two known lignans 6 and 7 were isolated after bioassay-directed fractionation. The structures and stereochemistries of the new compounds were determined by interpretation of NMR spectroscopy, mass spectrometry, and ECD spectra. Among these compounds, petradoriolide C (3) displayed the most potent antiplasmodial activity, with an IC50 value of 7.3 μM.

中文翻译：

抗疟原虫二萜类化合物和来自 Petradoria pumila 的苯托酚酮。

天然产物发现研究所的 Petradoria pumila 提取物被发现具有中等抗疟原虫活性，IC50 值在 5 至 10 μg/mL 之间。经过生物测定定向分馏后，分离出了四种新的二萜类 petradoriolides AD (1-4)、新的苯并托泊酮 petradoriolone (5) 以及两种已知的木脂素 6 和 7。通过核磁共振波谱、质谱和 ECD 谱的解释确定了新化合物的结构和立体化学。在这些化合物中，petradoriolide C (3) 显示出最有效的抗疟原虫活性，IC50 值为 7.3 μM。

更新日期：2018-05-08

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