This study aims to produce and optimize palm oil-based nano-emulsion to encapsulate curcumin using microfluidizer and Response Surface Methodology (RSM). Encapsulation of curcumin is essential to overcome curcumin's poor bioavailability through the formation of nano-sized droplets in order to harvest its outstanding anti-inflammatory and anti-cancer medicinal properties. Among the parameters of concern are microfluidizer's pressure, number of cycles and surfactant concentration (Tween 80). Optimisations were performed by employing RSM. Characterisations were conducted for the droplet size, poly-dispersity index (PDI), zeta potential (ZP) and viscosity. Stable palm oil-based oil in water nano-emulsion encapsulating curcumin was achieved at a droplet size of 275.5 nm, PDI of 0.257, ZP of −36.2 and viscosity of 446 cP using microfluidizer. The optimized conditions were at 350 bar, 5 cycles and 1 wt% surfactant. Optimized microfluidizer with the aid of RSM is deemed capable to produce palm oil-based oil in water nano-emulsion encapsulating curcumin with small droplet size using low surfactant concentration and under optimum energy consumption.

这项研究旨在使用微流化剂和响应表面方法（RSM）来生产和优化基于棕榈油的纳米乳剂来封装姜黄素。姜黄素的封装对于通过形成纳米级液滴克服姜黄素不良的生物利用度至关重要，以收获其出色的抗炎和抗癌药性。其中值得关注的参数是微射流器的压力，循环次数和表面活性剂浓度（吐温80）。通过使用RSM进行了优化。进行了液滴尺寸，多分散指数（PDI），ζ电位（ZP）和粘度的表征。使用微流化剂在275.5 nm的液滴尺寸，0.257的PDI，-36.2的ZP和446 cP的粘度下实现了封装姜黄素的稳定的棕榈油基水包油纳米乳剂。最适条件为350 bar，5个循环和1 wt％表面活性剂。人们认为，借助RSM进行优化的微流化器能够以较低的表面活性剂浓度并在最佳能量消耗下，以较小的液滴尺寸生产出包封姜黄素的棕榈油基水包油型纳米乳液。