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Simultaneous magnetic resonance and optical elastography acquisitions: Comparison of displacement images and shear modulus estimations using a single vibration source
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.9 ) Pub Date : 2018-05-08 , DOI: 10.1016/j.jmbbm.2018.05.010
Spencer T. Brinker , Steven P. Kearney , Thomas J. Royston , Dieter Klatt

The mechanical properties of tissue are sensitive to pathological changes, which is the basis for using dynamic elastography as a diagnostic tool. The purpose of this study is a concurrent cross-modality comparison of two dynamic elastography methods, Magnetic Resonance Elastography (MRE) and Scanning Laser Doppler Vibrometry (SLDV) using a single vibration source method. Cylindrical soft tissue mimicking specimens of Plastisol and Ecoflex are stimulated with 60, 100, 150, and 250 Hz sinusoidal vibration during imaging. Specimen stiffness was also varied by adjusting the softener amount in each material. Displacement fields acquired using the two methods show similarity in wave front geometry at all frequencies. Magnetic Resonance Elastography (MRE) with 3D inversion and Optical Elastography (OE) with averaged 1D curve fitting were used to derive complex shear moduli from each imaging modality. MRE and OE shear storage modulus (n = 3) results were closest at 150 Hz with Plastisol G’ (MRE) = 9.03 ± 0.43 kPa and G’ (OE) = 8.46 ± 0.14 kPa while Ecoflex was G’ (MRE) = 15.71 ± 0.95 kPa and G’ (OE) = 13.71 ± 0.03 kPa. Correlation between MRE and OE complex shear moduli related by all 36 coupled scans performed during this study yield a Pearson's correlation of ρ = 0.88 with p < 0.001 for G’ (storage modulus) and ρ = 0.85 with p < 0.001 for G” (loss modulus). The simultaneous imaging approach yields stiffness values within the same range and acceptable error margins for MRE and OE.



中文翻译:

同时进行磁共振和光学弹性成像采集:使用单个振动源比较位移图像和剪切模量估计值

组织的机械特性对病理变化敏感,这是使用动态弹性成像作为诊断工具的基础。这项研究的目的是同时使用两种振动弹性成像方法(磁共振弹性成像(MRE)和使用单个振动源方法的扫描激光多普勒振动测定法(SLDV))进行跨模态比较。在成像过程中,以60、100、150和250 Hz的正弦振动刺激模仿Plastisol和Ecoflex的圆柱状软组织标本。样品刚度也可以通过调节每种材料中的软化剂量来改变。使用这两种方法获得的位移场在所有频率下都显示出波前几何形状的相似性。具有3D反演的磁共振弹性成像(MRE)和具有平均1D曲线拟合的光学弹性成像(OE)用于从每个成像模态中导出复杂的剪切模量。MRE和OE剪切储能模量(n = 3)结果最接近150 Hz,其中Plastisol G'(MRE)= 9.03±0.43 kPa和G'(OE)= 8.46±0.14 kPa,而Ecoflex为G'(MRE)= 15.71 ±0.95 kPa和G'(OE)= 13.71±0.03 kPa 在此研究期间进行的所有36次耦合扫描相关的MRE和OE复数剪切模量之间的相关性产生了Pearson相关性,G'(存储模量)的p = 0.88,p <0.001;对于G',p <0.001,p = 0.85,P = 0.85(损失模数)。同时成像方法产生的MRE和OE的刚度值在相同范围内,并且可接受的误差容限。MRE和OE剪切储能模量(n = 3)结果最接近150 Hz,其中Plastisol G'(MRE)= 9.03±0.43 kPa和G'(OE)= 8.46±0.14 kPa,而Ecoflex为G'(MRE)= 15.71 ±0.95 kPa和G'(OE)= 13.71±0.03 kPa 在此研究期间进行的所有36次耦合扫描相关的MRE和OE复数剪切模量之间的相关性产生了Pearson相关性,G'(存储模量)的p = 0.88,p <0.001;对于G”,p <0.001,ρ= 0.85,(P'损失)模数)。同时成像方法产生的MRE和OE的刚度值在相同范围内,并且可接受的误差容限。MRE和OE剪切储能模量(n = 3)结果最接近150 Hz,其中Plastisol G'(MRE)= 9.03±0.43 kPa和G'(OE)= 8.46±0.14 kPa,而Ecoflex为G'(MRE)= 15.71 ±0.95 kPa和G'(OE)= 13.71±0.03 kPa 在此研究期间进行的所有36次耦合扫描相关的MRE和OE复数剪切模量之间的相关性产生了Pearson相关性,G'(存储模量)的p = 0.88,p <0.001;对于G',p <0.001,p = 0.85,P = 0.85(损失模数)。同时成像方法产生的MRE和OE的刚度值在相同范围内,并且可接受的误差容限。在此研究期间进行的所有36次耦合扫描相关的MRE和OE复数剪切模量之间的相关性产生了Pearson相关性,G'(存储模量)的p = 0.88,p <0.001;对于G',p <0.001,p = 0.85,P = 0.85(损失模数)。同时成像方法产生的MRE和OE的刚度值在相同范围内,并且可接受的误差容限。在此研究期间进行的所有36次耦合扫描相关的MRE和OE复数剪切模量之间的相关性产生了Pearson相关性,G'(存储模量)的p = 0.88,p <0.001;对于G',p <0.001,p = 0.85,P = 0.85(损失模数)。同时成像方法产生的MRE和OE的刚度值在相同范围内,并且可接受的误差容限。

更新日期:2018-05-08
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