Photodegradation kinetics of lisdexamfetamine dimesylate and structure elucidation of its degradation products by LC-ESI-QTOF,Analytical Methods

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Photodegradation kinetics of lisdexamfetamine dimesylate and structure elucidation of its degradation products by LC-ESI-QTOF
Analytical Methods ( IF 2.7 ) Pub Date : 2018-05-08 00:00:00 , DOI: 10.1039/c8ay00413g
Graciela Carlos _{1,

2,

3,

4,

5} , Jéferson Segalin _{4,

5,

6,

7,

8} , Louise Jank _{4,

5,

6,

7,

8} , Eloisa Comiran _{1,

2,

3,

4,

5} , Marcella Herbstrith de Oliveira _{1,

2,

3,

4,

5} , Pedro Eduardo Froehlich _{1,

2,

3,

4,

5}

Affiliation

Herein, we investigate the photodegradation of lisdexamfetamine (LDX) in an aqueous solution. The experiment is carried out by exposing the drug in solution to UV radiation for different periods of time during 48 h. The fragmentation pattern of LDX is established, and its two degradation products are identified (DP-01 and DP-02) and structurally characterized via liquid chromatography coupled with hybrid quadrupole time-of-flight electrospray ionization (LC-ESI-QTOF) mass spectrometry. Furthermore, the photodegradation kinetics of LDX is determined via LC-ESI-QTOF (r = 0.9905; k = 0.0204 h⁻¹; and t_1/2 = 33.91 h) and RP-LC-CAD (r = 0.9960; k = 0.0234 h⁻¹; and t_1/2 = 29.67 h). LDX is found to be unstable in the presence of light under the evaluated conditions.

中文翻译：

赖氨酸安非他明二甲酸酯的光降解动力学及其降解产物的结构解析（LC-ESI-QTOF）

本文中，我们研究了赖氨酸安非他明（LDX）在水溶液中的光降解。通过在48小时内将药物在溶液中暴露于紫外线辐射不同的时间段来进行实验。建立了LDX的片段化模式，并鉴定了它的两个降解产物（DP-01和DP-02），并通过液相色谱和混合四极杆飞行时间电喷雾电离（LC-ESI-QTOF）质谱进行结构表征。此外，LDX的光降解动力学通过LC-ESI-QTOF（r＝0.9905 ；k＝ 0.0204h ^-1；和t _1/2＝33.91h ）和RP-LC-CAD（r＝ 0.9960；t＝ 0.995；t＝ 1.905 ；k＝ 0.095h ^-₁）确定。k = 0.0234 h ^-1 ; 和t _1/2 = 29.67 h）。发现LDX在评估条件下在有光的情况下是不稳定的。

更新日期：2018-05-08

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