Ligand libraries for high throughput screening of homogeneous catalysts,Chemical Society Reviews

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Ligand libraries for high throughput screening of homogeneous catalysts
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-05-08 00:00:00 , DOI: 10.1039/c7cs00844a
Marc Renom-Carrasco _{1,

2,

3,

4} , Laurent Lefort _{5,

6,

7}

Affiliation

To accelerate the discovery of new or improved homogeneous catalysts, research groups in industry and academia have embraced high throughput experimentation (HTE). Such methodologies consist of preparing and testing large numbers of catalysts in parallel. Homogeneous metal catalysts are very well-suited for HTE, since in many cases, they can be prepared by simply mixing a metal precursor and a ligand. However, an HTE program requires a large set of chemically diverse ligands, i.e. a ligand library. In this review, we describe five different approaches for assembling ligand libraries based on an extensive survey of the literature. These approaches are based on commercial ligands, modular ligands, mixtures of ligands, supramolecular ligands or ligands prepared via the tools of biochemistry.

中文翻译：

用于高通量均相催化剂筛选的配体库

为了加速发现新的或改良的均相催化剂，工业界和学术界的研究小组采用了高通量实验（HTE）。这种方法包括并行制备和测试大量催化剂。均相金属催化剂非常适合HTE，因为在许多情况下，它们可以通过简单地将金属前体和配体混合来制备。但是，HTE程序需要大量化学上不同的配体，即配体库。在这篇综述中，我们根据广泛的文献描述了五种不同的组装配体库的方法。这些方法基于商业配体，模块化配体，配体混合物，超分子配体或通过生化工具。

更新日期：2018-05-08

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