Solid-phase organic synthesis is a powerful tool in the synthesis of small organic molecules and building of libraries of compounds for drug discovery. Heterocyclic compounds are important components of the drug discovery field as well and serve as a core for hundreds of marketed drugs. In particular, oxadiazole and thiadiazole cores are compounds of great interest due to their comprehensive biological activities and structural features. Therefore, a plethora of oxadiazole and thiadiazole synthesis methodologies have been reported to date, including solution and solid-phase synthesis methodologies. In this review, we concentrate on and summarize solid-phase synthetic approaches of the oxadiazole and thiadiazole derivatives.

中文翻译：

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目前用于组合化学的类恶二唑和噻二唑衍生物的并行固相合成

固相有机合成是合成小的有机分子和建立用于药物发现的化合物库的有力工具。杂环化合物也是药物发现领域的重要组成部分，并且是数百种市售药物的核心。尤其是，恶二唑和噻二唑核是令人关注的化合物，因为它们具有全面的生物学活性和结构特征。因此，迄今为止，已经报道了过多的恶二唑和噻二唑合成方法，包括溶液和固相合成方法。在这篇综述中，我们集中于并总结了恶二唑和噻二唑衍生物的固相合成方法。