Abstract The main ingredients used in e-liquid formulations (propylene glycol (PG), vegetable glycerol (VG), and nicotine (Nic)) in a total of 16 retail e-liquids (half containing nicotine)) were analyzed by an analytical method developed recently by our research group. The measured nicotine concentrations in e-liquids varied in a range of 5.7 to 14.7 mg g−1 and differed up to 9.0% from the declared label concentrations (two tailed P = 0.5424 at a 0.05 confidence level). The concentrations of Nic and PG in vaped aerosol samples were lower (by an average of 12.7% and 17.4%, respectively) than those in e-liquid samples, while the opposite was true for VG (1.95% higher on average). The composition (w/w) of 16 retail e-liquids varied: 82.6 to 94.9% PG + VG (n = 16), 0.68 to 1.63% nicotine (n = 8), and 5.1 to 16.2% unidentified compounds (water, flavors, etc., n = 16). For the corresponding vaped aerosols, the results were: 75.4 to 92.1% PG + VG (n = 16), 0.57 to 1.47% nicotine (n = 8), and 7.86 to 24.0% unidentified compounds (water, flavors, etc., n = 16). The relative proportion of unidentified compounds in vaped aerosols was two times higher than those in e-liquids. The mean nicotine vaping emission factor (39.6 μg puff−1) was about two times lower than that of a Kentucky 2R4F reference cigarette (75 μg puff−1). The measured e-cigarette vaping emission factors varied in a range of 22.5–61.5 μg Nic puff−1 (n = 8), 1.04–2.45 mg PG puff−1 (n = 16), and 1.35–2.09 mg VG puff−1 (n = 16).

中文翻译：

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零售电子烟液体和雾化气雾剂中尼古丁和主要溶剂的定量

摘要 通过分析方法对总共 16 种零售电子烟油（一半含尼古丁）中的电子烟油配方中使用的主要成分（丙二醇 (PG)、植物甘油 (VG) 和尼古丁 (Nic)）进行了分析。最近由我们的研究小组开发。电子液体中测得的尼古丁浓度在 5.7 至 14.7 mg g-1 的范围内变化，与声明的标签浓度相差高达 9.0%（两个尾 P = 0.5424，置信水平为 0.05）。电子烟气溶胶样品中 Nic 和 PG 的浓度低于电子烟油样品中的浓度（平均分别为 12.7% 和 17.4%），而 VG 则相反（平均高 1.95%）。16 种零售电子烟油的成分 (w/w) 各不相同：82.6% 至 94.9% PG + VG（n = 16）、0.68% 至 1.63% 尼古丁（n = 8）和 5.1% 至 16.2% 未识别化合物（水、口味等，n = 16）。对于相应的雾化气雾剂，结果为：75.4 至 92.1% PG + VG（n = 16）、0.57 至 1.47% 尼古丁（n = 8）和 7.86 至 24.0% 未识别化合物（水、香料等，n = 16）。雾化气溶胶中不明化合物的相对比例是电子烟油中的两倍。平均尼古丁电子烟排放因子（39.6 μg puff-1）比肯塔基州 2R4F 参考卷烟（75 μg puff-1）低约两倍。测量的电子烟 vaping 排放因子在 22.5–61.5 μg Nic puff−1 (n = 8)、1.04–2.45 mg PG puff−1 (n = 16) 和 1.35–2.09 mg VG puff−1 的范围内变化(n = 16)。n = 16）。雾化气溶胶中不明化合物的相对比例是电子烟油中的两倍。平均尼古丁电子烟排放因子（39.6 μg puff-1）比肯塔基州 2R4F 参考卷烟（75 μg puff-1）低约两倍。测量的电子烟 vaping 排放因子在 22.5–61.5 μg Nic puff−1 (n = 8)、1.04–2.45 mg PG puff−1 (n = 16) 和 1.35–2.09 mg VG puff−1 的范围内变化(n = 16)。n = 16）。雾化气溶胶中不明化合物的相对比例是电子烟油中的两倍。平均尼古丁电子烟排放因子（39.6 μg puff-1）比肯塔基州 2R4F 参考卷烟（75 μg puff-1）低约两倍。测量的电子烟 vaping 排放因子在 22.5–61.5 μg Nic puff−1 (n = 8)、1.04–2.45 mg PG puff−1 (n = 16) 和 1.35–2.09 mg VG puff−1 的范围内变化(n = 16)。