A novel tetrahydrofuran derivative, trigonohowine (1), together with five known tetrahydrofuran derivatives (2–6), were isolated from the stems and leaves of Trigonostemon howii. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with the data reported in literature. Among them, trigonohowine (1) represents the first example of a new type of tetrahydrofuran derivative, possessing an unprecedented carbon skeleton containing 23 carbon atoms on the carbon skeleton and the known compouds (2–6) are rare tetrahydrofuran derivatives in the plant kingdom with various carbon skeletons. All isolated compounds were evaluated for their anti-HIV-1 activities. Compounds 1–6 showed significant anti-HIV-1 activities with EC₅₀ ranged from 0.08 to 1.03 µM. These findings suggest that the discoveries of these tetrahydrofuran derivatives with significant anti-HIV-1 activities isolated from T. howii could be of great importance to the development of new anti-HIV agents.

一种新颖的四氢呋喃衍生物，trigonohowine（1）中，用5个已知四氢呋喃衍生物（共同2 - 6），进行分离从茎叶三宝木属howii。通过广泛的光谱学方法阐明了1的结构，并通过与文献报道的数据进行比较来鉴定了已知化合物。其中，trigonohowine（1）代表的新型四氢呋喃衍生物的第一个例子，具有前所未有的碳骨架上含有碳骨架23个碳原子和已知的组分（PC）（2 - 6）是植物界中稀有的具有各种碳骨架的四氢呋喃衍生物。评价所有分离的化合物的抗HIV-1活性。化合物1 - 6表现出显著的抗HIV-1活性用EC ₅₀范围从0.08到1.03微米。这些发现表明，从How.T.ii分离出的具有显着抗HIV-1活性的四氢呋喃衍生物的发现可能对开发新的抗HIV药物具有重要意义。