Lack of known mechanisms of protection against Staphylococcus aureus in humans represents an important risk factor for skin infections and bacteremia in patients, intern hindering the development of efficacious vaccines. However, development of effective humoral response may be dampened by converging immune-evasion mechanisms of S. aureus. To develop a promising vaccine against S. aureus, it is pre-requisite to clear understanding of cutaneous, innate and adaptive immune response. The S. aureus dampening the humoral response, T cell help, blocking complement factors, and killing immune players by its toxins are the important factors need to understand clearly. We hypothesized that the master mechanism of S. aureus counteracts may hindering the immune action which may result in failure of target-oriented vaccine development. Developing immunological interventions that can effectively block the S. aureus counteracting mechanisms are the key success for a developing vaccine for the future was warranted.

缺乏针对人的金黄色葡萄球菌保护的已知机制代表了患者皮肤感染和菌血症的重要危险因素，这阻碍了有效疫苗的开发。然而，通过融合金黄色葡萄球菌的免疫逃逸机制可以抑制有效的体液反应的发展。要开发针对金黄色葡萄球菌的有前途的疫苗，必须清楚了解皮肤，先天和适应性免疫应答。在金黄色葡萄球菌润体液反应，辅助性T细胞，阻断补体因子，并通过其毒素杀死免疫球员都是重要的因素需要了解清楚。我们假设金黄色葡萄球菌的主要机制相互作用可能会阻碍免疫作用，从而可能导致靶向疫苗的开发失败。有必要开发能够有效阻断金黄色葡萄球菌抵消机制的免疫干预措施，这是未来开发疫苗的关键成功。