In mammals, cochlear hair cells have a pivotal role in transducing mechanical energy into electrical signals. Cochlear hair cells are sensitive to acoustic trauma, drug insults, aging, and environmental or genetic influences that can cause permanent hearing loss. Currently, much research is focusing on noise-induced sensorineural hearing loss (SNHL). Noise-induced SNHL is primarily caused by damage to hair cells of the cochlear sensory epithelium. Here, we summarize progress in restoring the sensory epithelium after SNHL resulting from noise exposure. The prevalent strategy to regenerate cochlear hair cells is through transdifferentiation of the supporting cells through the activation of the NOTCH 1 pathway.

在哺乳动物中，耳蜗毛细胞在将机械能转化为电信号中起着关键作用。耳蜗毛细胞对听觉创伤，药物侮辱，衰老以及可能导致永久性听力损失的环境或遗传因素敏感。当前，许多研究集中在噪声引起的感觉神经性听力损失（SNHL）。噪声引起的SNHL主要是由耳蜗感觉上皮的毛细胞受损引起的。在这里，我们总结了噪声暴露引起的SNHL后恢复感觉上皮的进展。再生耳蜗毛细胞的普遍策略是通过激活NOTCH 1途径使支持细胞发生转分化。