Background

Prurigo nodularis (PN) is a poorly understood, understudied pruritic dermatosis that reduces quality of life.

Objective

To characterize the demographics and comorbidities associated with PN.

Methods

Cross-sectional study of patients 18 years and older who were seen at the Johns Hopkins Health System between December 6, 2012, and December 6, 2017.

Results

Over the past 5 years, 909 patients with PN were seen at Johns Hopkins Health System. African American patients were 3.4 times more likely to have PN than white patients were (odds ratio [OR], 3.4; 95% confidence interval [CI], 2.9-3.9; P < .001). A comparison of the study patients and race-matched controls revealed that PN was significantly associated with a variety of systemic, cardiovascular, and psychiatric comorbidities, including chronic kidney disease, chronic hepatitis C, chronic obstructive pulmonary disease, congestive heart failure, depression, and atopic dermatitis. Black patients with PN were 10.5 times more likely (OR, 10.5; 95% CI, 7.9-13.9; P < .001) to have HIV than were race-matched controls with atopic dermatitis, and 8 times more likely (OR, 8.0; 95% CI, 5.7-11.1; P < .001) to have HIV than were African American patients with psoriasis.

Limitations

Our data describe patients seen by 1 hospital system. Our data identify associated conditions and comorbidities but are unable to support a causal relationship.

Conclusion

PN disproportionately affects African Americans and is associated with several systemic conditions, including HIV, chronic kidney disease, and diabetes.

中文翻译：

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909例结节性痒疹患者的种族差异及合并症

背景

结节性痒疹 (PN) 是一种知之甚少、研究不足的瘙痒性皮肤病，可降低生活质量。

客观的

表征与 PN 相关的人口统计学和合并症。

方法

对 2012 年 12 月 6 日至 2017 年 12 月 6 日在约翰霍普金斯卫生系统就诊的 18 岁及以上患者进行的横断面研究。

结果

在过去的 5 年中，约翰霍普金斯卫生系统共接诊了 909 名 PN 患者。非裔美国人患者发生 PN 的可能性是白人患者的 3.4 倍（优势比 [OR]，3.4；95% 置信区间 [CI]，2.9-3.9；P  < .001）。对研究患者和种族匹配对照的比较显示，PN 与多种全身、心血管和精神合并症显着相关，包括慢性肾病、慢性丙型肝炎、慢性阻塞性肺病、充血性心力衰竭、抑郁症和特应性皮炎。患有 PN 的黑人患者 感染 HIV 的可能性是具有特应性皮炎的种族匹配对照者的 10.5 倍（OR，10.5；95% CI，7.9-13.9；P < .001），并且是其 8 倍（OR，8.0； 95% CI，5.7-11.1；P  < .001) 比非洲裔美国银屑病患者感染 HIV。

限制

我们的数据描述了 1 个医院系统就诊的患者。我们的数据确定了相关的病症和合并症，但无法支持因果关系。

结论

PN 不成比例地影响非裔美国人，并与多种全身性疾病有关，包括 HIV、慢性肾病和糖尿病。