当前位置: X-MOL 学术Neurosci Biobehav Rev › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Basal Ganglia and Beyond: the interplay between motor and cognitive aspects in Parkinson’s disease Rehabilitation
Neuroscience & Biobehavioral Reviews ( IF 7.5 ) Pub Date : 2018-05-04
Davide Ferrazzoli, Paola Ortelli, Graziella Madeo, Nir Giladi, Giselle M. Petzinger, Giuseppe Frazzitta

Parkinson’s disease (PD) is characterized by motor and cognitive dysfunctions, affecting the motor behaviour. We summarize evidence that the interplay between motor and cognitive approaches is crucial in PD rehabilitation. Rehabilitation is complementary to pharmacological therapy and effective in reducing the PD disturbances, probably acting by inducing neuroplastic effects.

The motor behaviour results from a complex integration between cortical and subcortical areas, underlying the motor, cognitive and motivational aspects of movement. The close interplay amongst these areas makes possible to learn, control and express habitual-automatic actions, which are dysfunctional in PD.

The physiopathology of PD could be considered the base for the development of effective rehabilitation treatments. As the volitional action control is spared in early-medium stages of disease, rehabilitative approaches engaging cognition permit to achieve motor benefits and appear to be the most effective for PD.

We will point out data supporting the relevance of targeting both motor and cognitive aspects in PD rehabilitation. Finally, we will discuss the role of cognitive engagement in motor rehabilitation for PD.



中文翻译:

基底节和超越:帕金森氏病康复中运动和认知方面的相互作用

帕金森氏病(PD)的特征是运动和认知功能障碍,影响运动行为。我们总结了证据,运动和认知方法之间的相互作用在PD康复中至关重要。康复是药物治疗的补充,可有效减少PD紊乱,可能是通过诱导神经增生作用而起作用。

运动行为是皮质和皮质下区域之间复杂的整合所致,是运动,认知和动机方面的基础。这些区域之间的密切相互作用使学习,控制和表达习惯性自动动作成为可能,而习惯性自动动作在PD中是功能失调的。

PD的生理病理学可以被认为是发展有效的康复治疗的基础。由于在疾病的中早期阶段就没有采取主动行动控制措施,因此采用认知的康复方法可以实现运动功能,并且似乎对PD最为有效。

我们将指出支持PD康复中针对运动和认知方面的相关性的数据。最后,我们将讨论认知参与在PD运动康复中的作用。

更新日期:2018-05-04
down
wechat
bug