Cardiac troponin I (cTnI) is a specific and sensitive biomarker for the early diagnosis of acute myocardial infarction and for the subsequent clinical treatments. In this work, novel electrochemical sensing platform for sensing of cTnI based on aptamer-MoS₂ nanoconjugates was proposed. For comparison, core-shell [email protected]₂@Au nanoparticles were also used for sensing of cTnI. The sensing schemes and electrochemical responses of the proposed sensors were investigated by electrochemical impedance spectroscopy (EIS) in 5.0 mM K₃[Fe(CN)₆]/K₄[Fe(CN)₆] (1:1) solution containing 0.1 M KCl, respectively. Results showed that the [email protected]₂@Au based aptasensor shows a linear rage of 10 pM-10.0 μM with the detection limits of 1.23 pM For the aptamer-MoS₂ nanosheets based aptasensor, the linear range for cTnI detection was from 10 pM to 1.0 μM with a lower detection limit of 0.95 pM Meanwhile, both the sensors were successfully applied for detection of cTnI in human blood samples. The two kinds of aptsensors have been successfully used for detecting of cTnI in human blood serums. Moreover, no negligible signal changes could be observed in the presence of non-targets of CK-MB and Myo, suggesting the good potential for clinic diagnosis.

心肌肌钙蛋白I（cTnI）是急性心肌梗死的早期诊断和随后的临床治疗的一种特异性和敏感的生物标志物。在这项工作中，提出了一种新型的基于适体-MoS ₂纳米共轭物的cTnI电化学传感平台。为了进行比较，还使用了核-壳[电子邮件保护的] ₂ @Au纳米颗粒来检测cTnI。通过电化学阻抗谱（EIS）在含有0.1 M的5.0 mM K ₃ [Fe（CN）₆ ] / K ₄ [Fe（CN）₆ ]（1：1）溶液中，研究了拟议传感器的传感方案和电化学响应。氯化钾。结果表明，[电子邮件保护] ₂基于@Au的适体传感器的线性范围为10 pM - 10.0μM，检出限为1.23 pM对于基于aptamer-MoS ₂纳米片的适体传感器，cTnI检测的线性范围为10 pM至1.0μM，较低的检出限为0.95 pM同时，这两种传感器都已成功应用于人血样品中cTnI的检测。两种自适应传感器已成功用于检测人血清中的cTnI。此外，在CK-MB和Myo的非靶标存在下，没有观察到微不足道的信号变化，提示其在临床诊断中的良好潜力。