Remote Asymmetric Induction Reactions using a E,E-Vinylketene Silyl N,O-Acetal and the Wide Range Stereocontrol Strategy for the Synthesis of Polypropionates,Accounts of Chemical Research

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Remote Asymmetric Induction Reactions using a E,E-Vinylketene Silyl N,O-Acetal and the Wide Range Stereocontrol Strategy for the Synthesis of Polypropionates
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-05-04 00:00:00 , DOI: 10.1021/acs.accounts.8b00125
Seijiro Hosokawa ₁

Affiliation

The construction of libraries of acyclic polyketides remains a challenging topic, mostly due to the difficulties associated with finding the right balance between diversity and brevity for the synthetic routes leading to polyketides. Recently, relatively short methods have been developed and applied to the synthesis of natural products. However, these short routes often suffer from limited diversity with respect to the arrangement of functional groups and stereochemistry, as these usually require reactions that direct multiple functional groups simultaneously in one step. Therefore, methods that combine a small number of reaction steps with structural diversity remain an attractive research target for the construction of acyclic polyketide libraries.

中文翻译：

E，E-乙烯基乙烯酮甲硅烷基N，O-缩醛的远程不对称诱导反应和聚丙烯酸酯合成的大范围立体控制策略

建立无环聚酮化合物的文库仍然是一个具有挑战性的话题，这主要是由于难以找到导致聚酮化合物的合成路线在多样性和简洁性之间取得正确平衡所带来的困难。近来，已经开发了相对短的方法并将其应用于天然产物的合成。然而，这些短路径通常在功能基团的排列和立体化学方面受到有限的多样性的困扰，因为这些通常需要在一个步骤中同时引导多个功能基团的反应。因此，将少量反应步骤与结构多样性相结合的方法仍然是构建无环聚酮化合物库的有吸引力的研究目标。

更新日期：2018-05-04

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