Oncosis is a non-apoptotic form of programmed cell death (PCD), which differs from apoptosis in both morphological changes and inner pathways, and might hold the key to defeating a major obstacle in cancer therapy – drug-resistance, which is often a result of the intrinsic apoptosis resistance of tumours. However, despite the fact that the term “oncosis” was coined and used much earlier than apoptosis, little effort has been made to discover new drugs which can initiate this form of cell death, in comparison to drugs inducing apoptosis or any other type of PCD. So herein, we present the synthesis of a series of mitochondria-targeting cyclometalated Ir(III) complexes, which activated the oncosis-specific protein porimin and calpain in cisplatin-resistant cell line A549R, and determined their cytotoxicity against a wide range of drug-resistant cancer types. To the best of our knowledge, these complexes are the very first metallo-components to induce oncosis in drug-resistant cancer cells.

中文翻译：

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诱导肿瘤的环金属化铱（iii）配合物†

肿瘤病是程序性细胞死亡（PCD）的一种非凋亡形式，在形态学改变和内部途径方面均不同于凋亡，并且可能是克服癌症治疗中主要障碍的关键-耐药性，这通常是由于固有的细胞凋亡抗性 然而，尽管事实是“肿瘤”一词的产生和使用早于细胞凋亡，但与诱导细胞凋亡或任何其他类型PCD的药物相比，人们几乎没有做出任何努力来发现可以引发这种细胞死亡形式的新药物。 。因此，在本文中，我们介绍了一系列靶向线粒体的环金属化Ir（III）配合物，该配合物在顺铂耐药细胞系A549R中激活了肿瘤特异性蛋白porimin和calpain，并确定了它们对多种耐药癌症的细胞毒性。据我们所知，这些复合物是在耐药性癌细胞中诱导肿瘤形成的最早的金属成分。