A novel method for the quantitative determination of chlorinated paraffins (CPs) was developed using bromide-anion attachment atmospheric-pressure chemical ionization mass spectrometry (APCI-MS). Bromoform was used to enhance ionization of CPs. Near exclusive formation of stable bromide adduct ions ([M + Br]⁻) enabled accurate detection of individual CP congener groups (C_nCl_m) with only a moderate-resolution quadrupole time-of-flight mass spectrometer. Furthermore, the method was free from interference commonly observed with chloride-anion attachment methods (e.g., decomposition ions [M + Cl – HCl]⁻) that require deconvolution. Together with a C_nCl_m-response-factor algorithm for quantifying short-chain CPs and a C_nCl_m-pattern-reconstruction algorithm for quantifying medium- and long-chain CPs, method applicability was demonstrated on biota and sediment samples. These data were generated significantly faster and with improved selectivity and sensitivity versus those of conventional measurements by chloride-anion attachment APCI-MS.

中文翻译：

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溴阴离子连接大气压化学电离质谱法测定氯化石蜡

建立了一种使用溴化物-阴离子附着大气压化学电离质谱法（APCI-MS）定量测定氯化石蜡（CPs）的新方法。溴仿用于增强CP的电离。稳定的溴化物加合物离子（[M + Br] ^-）几乎全部形成，仅使用中等分辨率的四极杆飞行时间质谱仪即可准确检测单个CP同系物基团（C _n Cl _m）。此外，该方法不受需要反卷积的氯离子阴离子附着方法（例如，分解离子[M + Cl – HCl] ^-）通常观察到的干扰。与C _n Cl _m一起响应因子算法用于量化短链CP和C _n Cl _m模式重构算法用于量化中链和长链CP，证明了该方法在生物群和沉积物样品上的适用性。这些数据的生成速度显着加快，并且选择性和灵敏度得到了提高，与采用氯阴离子连接APCI-MS进行常规测量相比，具有更高的选择性和灵敏度。