Determination of Cu2+ and biothiols by novel red fluorescent hybrid nanoparticles†,Analytical Methods

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Determination of Cu2+ and biothiols by novel red fluorescent hybrid nanoparticles†
Analytical Methods ( IF 2.7 ) Pub Date : 2018-05-02 00:00:00 , DOI: 10.1039/c8ay00614h
Ling Zhang _{1,

2,

3,

4} , Zizhun Wang _{1,

2,

3,

4} , Jiaze Hou _{1,

2,

3,

4} , Lulu Lei _{1,

2,

3,

4} , Jiao Li _{1,

2,

3,

4} , Juan Bai _{1,

2,

3,

4} , Hui Huang _{1,

2,

3,

4} , Yongxin Li _{4,

5,

6,

7,

8}

Affiliation

Red fluorescent hybrid nanoparticles (NPG@PFBD) have been designed and synthesized successfully. The NPG@PFBD nanoparticles are composed of a fluorescent semiconducting polymer (PFBD) and n-propyl gallate (NPG). Because of the coordination between the gallate and Cu²⁺, Cu²⁺ could attach to the hybrid nanoparticles and quench their fluorescence through photoinduced electron transfer (PET). In addition, in the presence of biothiols, such as glutathione (GSH), Cu²⁺ would bind to the thiol. The PET between the hybrid nanoparticles and Cu²⁺ was weakened, and the fluorescence signal of the nanoparticles was recovered. A facile detection method for Cu²⁺ and biothiols was therefore developed. The detection limit for Cu²⁺ and GSH was 40 nM and 90 nM, respectively. The proposed fluorescent hybrid nanoparticles have great potential application for Cu²⁺ and GSH detection in related biological fields.

中文翻译：

新型红色荧光杂化纳米颗粒测定铜²⁺和生物硫醇†

红色荧光杂化纳米粒子（NPG @ PFBD）已被成功设计合成。NPG @ PFBD纳米粒子由荧光半导体聚合物（PFBD）和没食子酸正丙酯（NPG）组成。由于没食子酸酯和Cu ²⁺之间的配位，Cu ²⁺可以附着在杂化纳米颗粒上并通过光致电子转移（PET）猝灭其荧光。另外，在存在生物硫醇如谷胱甘肽（GSH）的情况下，Cu ²⁺会与硫醇结合。杂化纳米粒子与Cu ²⁺之间的PET减弱，纳米粒子的荧光信号得以恢复。Cu ^2+的简便检测方法因此开发了生物硫醇。Cu ²⁺和GSH的检出限分别为40 nM和90 nM。提出的荧光杂化纳米粒子在相关生物领域中对Cu ²⁺和GSH的检测具有巨大的潜在应用价值。

更新日期：2018-05-02

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