The inhibition of pathogenic bacteria at the replication stage is important to halt their further reproduction and spread. The replication enzymes include the DNA gyrase and topoisomerase IV that are recognized targets for the infection control. Novel antibiotic compounds are always in demand for targeting different active sites of these enzymes. Although quinolones are the current drug of choice for targeting these enzymes, emerging resistance is a global concern. Wide-scale efforts are needed to overcome the emerging resistance by designing more potent drugs. In this article, we have reviewed the last five years progress of various classes of non-quinolone-based chemical compounds that are tested for their antibacterial activities.

在复制阶段抑制病原细菌对于阻止其进一步繁殖和传播很重要。复制酶包括DNA促旋酶和拓扑异构酶IV，它们被认为是感染控制的靶标。始终需要针对这些酶的不同活性位点的新型抗生素化合物。尽管喹诺酮是目前针对这些酶的选择药物，但新出现的耐药性已成为全球关注的问题。通过设计更有效的药物，需要进行广泛的努力来克服新出现的耐药性。在本文中，我们回顾了各种基于非喹诺酮类化合物的抗菌活性最近五年的研究进展。