Copper/Diboron‐Mediated Intramolecular Oxygenation and Allylation/Benzylation of Nitroalkynes for the Synthesis of C2‐Quaternary Indolin‐3‐ones,Chemistry - An Asian Journal

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Copper/Diboron‐Mediated Intramolecular Oxygenation and Allylation/Benzylation of Nitroalkynes for the Synthesis of C2‐Quaternary Indolin‐3‐ones
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-06-17 , DOI: 10.1002/asia.201800500
Wenqiang Fu ₁ , Yao Zhou ₁ , Qiuling Song ₁

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A direct strategy for intramolecular transfer oxygenation of alkynes and cycloisomerization of 2‐nitroalkynes to synthesize a wide range of C2‐quaternary indolin‐3‐ones was developed by a copper/diboron system. The desired allylation, benzylation and propargylation products were obtained in moderate to excellent yields with good functional group tolerance. The mechanism study indicated that this protocol involved a radical process.

中文翻译：

铜/二硼介导的硝基炔的分子内氧合和烯丙基化/苄基化反应，用于合成C2-季吲哚-3-酮

通过铜/二硼体系开发了一种直接进行炔烃分子内转移氧合和2-硝基炔烃的环异构化以合成各种C2-季吲哚-3-酮的直接策略。以中等至优异的产率和良好的官能团耐受性获得了所需的烯丙基化，苄基化和炔丙基化产物。机制研究表明，该协议涉及一个根本过程。

更新日期：2018-06-17

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