Intraperitoneal metastasis is a common occurrence and is usually involved in the poor prognosis of ovarian cancer. Its specific metastatic pattern implies that certain indispensable microenvironmental factors secreted in the peritoneal cavity can direct metastatic ovarian cancer cells to permissive niches for secondary lesion formation. However, the underlying molecular mechanisms are ill defined. Herein, we report that GRO-α and IL-8 are predominately upregulated in culture media derived from either normal or cancerous omenta and are associated with increased ovarian cancer aggressiveness.

中文翻译：

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GRO-α和IL-8通过CXCR2介导的TAK1 /NFκB信号级联反应增强卵巢癌的转移潜能

腹腔转移是常见的现象，通常与卵巢癌的不良预后有关。其特定的转移模式意味着腹膜腔中分泌的某些必不可少的微环境因素可以将转移性卵巢癌细胞引导至允许的壁ches，以形成继发性病变。但是，潜在的分子机制尚不明确。在本文中，我们报道GRO-α和IL-8在源自正常或癌性全谷物的培养基中主要上调，并与卵巢癌的侵袭性增加相关。