Longitudinal Multiplexed Measurement of Quantitative Proteomic Signatures in Mouse Lymphoma Models Using Magneto-Nanosensors.,Theranostics

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Longitudinal Multiplexed Measurement of Quantitative Proteomic Signatures in Mouse Lymphoma Models Using Magneto-Nanosensors.
Theranostics ( IF 12.4 ) Pub Date : 2018-02-03 , DOI: 10.7150/thno.20706
Jung-Rok Lee ₁ , Iris Appelmann _{2,

3} , Cornelius Miething _{2,

4} , Tyler O Shultz ₅ , Daniel Ruderman ₆ , Dokyoon Kim ₅ , Parag Mallick ₇ , Scott W Lowe ₂ , Shan X Wang _{5,

7,

8}

Affiliation

Cancer proteomics is the manifestation of relevant biological processes in cancer development. Thus, it reflects the activities of tumor cells, host-tumor interactions, and systemic responses to cancer therapy. To understand the causal effects of tumorigenesis or therapeutic intervention, longitudinal studies are greatly needed. However, most of the conventional mouse experiments are unlikely to accommodate frequent collection of serum samples with a large enough volume for multiple protein assays towards single-object analysis. Here, we present a technique based on magneto-nanosensors to longitudinally monitor the protein profiles in individual mice of lymphoma models using a small volume of a sample for multiplex assays.

中文翻译：

使用磁纳米传感器对小鼠淋巴瘤模型中定量蛋白质组学特征进行纵向多重测量。

癌症蛋白质组学是癌症发展中相关生物过程的表现。因此，它反映了肿瘤细胞的活性、宿主与肿瘤的相互作用以及对癌症治疗的全身反应。为了了解肿瘤发生或治疗干预的因果影响，非常需要纵向研究。然而，大多数传统的小鼠实验不太可能适应频繁收集足够大体积的血清样本，以进行单目标分析的多种蛋白质测定。在这里，我们提出了一种基于磁纳米传感器的技术，使用少量样品进行多重测定，纵向监测淋巴瘤模型个体小鼠的蛋白质谱。

更新日期：2018-05-01

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