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Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis
Theranostics ( IF 12.4 ) Pub Date : 2018-02-03 , DOI: 10.7150/thno.21072
Stella Cosenza , Karine Toupet , Marie Maumus , Patricia Luz-Crawford , Olivier Blanc-Brude , Christian Jorgensen , Danièle Noël

Objectives: Mesenchymal stem cells (MSCs) release extracellular vesicles (EVs) that display a therapeutic effect in inflammatory disease models. Although MSCs can prevent arthritis, the role of MSCs-derived EVs has never been reported in rheumatoid arthritis. This prompted us to compare the function of exosomes (Exos) and microparticles (MPs) isolated from MSCs and investigate their immunomodulatory function in arthritis.

中文翻译:

在炎症性关节炎中,间充质干细胞来源的外来体比微粒更具有免疫抑制作用

目的:间充质干细胞(MSC)释放细胞外囊泡(EVs),在炎症性疾病模型中显示出治疗效果。尽管MSC可以预防关节炎,但从未报道过MSC衍生的电动汽车在类风湿性关节炎中的作用。这促使我们比较了外泌体(Exos)和分离自MSC的微粒(MP)的功能,并研究了它们在关节炎中的免疫调节功能。
更新日期:2018-05-01
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