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Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells
Theranostics ( IF 12.4 ) Pub Date : 2018-02-04 , DOI: 10.7150/thno.21906
Michaela Oeller , Sandra Laner-Plamberger , Sarah Hochmann , Nina Ketterl , Martina Feichtner , Gabriele Brachtl , Anna Hochreiter , Cornelia Scharler , Lara Bieler , Pasquale Romanelli , Sebastien Couillard-Despres , Elisabeth Russe , Katharina Schallmoser , Dirk Strunk

Intravascular transplantation of tissue factor (TF)-bearing cells elicits an instant blood-mediated inflammatory reaction (IBMIR) resulting in thrombotic complications and reduced engraftment. Here we studied the hemocompatibility of commonly used human white adipose tissue (WAT), umbilical cord (UC) and bone marrow stromal cells (BMSC) and devised a possible strategy for safe and efficient stromal cell transplantation.

中文翻译:

组织因子缺陷型细胞移植的选择作为改善人类骨髓基质细胞血液相容性的新策略。

携带组织因子(TF)的细胞的血管内移植会引起即时的血液介导的炎症反应(IBMIR),从而导致血栓形成并发症并减少植入。在这里,我们研究了常用的人类白色脂肪组织(WAT),脐带(UC)和骨髓基质细胞(BMSC)的血液相容性,并提出了安全有效的基质细胞移植的可能策略。
更新日期:2018-05-01
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