Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System,Theranostics

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Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System
Theranostics ( IF 12.4 ) Pub Date : 2018-02-02 , DOI: 10.7150/thno.22662
Maxime Gauberti _{1,

2} , Antoine P Fournier ₁ , Fabian Docagne ₁ , Denis Vivien _{1,

3} , Sara Martinez de Lizarrondo ₁

Affiliation

Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), P-Selectin and E-Selectin. We also discuss the perspectives and challenges for the clinical application of this technology in neurovascular disorders (ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage, diabetes mellitus), neuroinflammatory disorders (multiple sclerosis, brain infectious diseases, sepsis), neurodegenerative disorders (Alzheimer's disease, vascular dementia, aging) and brain cancers (primitive neoplasms, metastasis).

中文翻译：

中枢神经系统内皮激活的分子磁共振成像

中枢神经系统的内皮细胞在神经系统疾病期间过度表达表面蛋白，这可能是疾病的原因，也可能是疾病的结果。由于携带对比剂的大颗粒很容易进入脑血管系统，因此它成为分子磁共振成像 (MRI) 的首选目标。在这篇综述中，我们重点介绍了脑内皮激活分子 MRI 的最新进展，并重点关注针对粘附分子（包括细胞间粘附分子 1 (ICAM-1)、血管细胞粘附）的微米级氧化铁颗粒 (MPIO) 的开发分子 1 (VCAM-1)、P-选择素和 E-选择素。我们还讨论了该技术在神经血管疾病（缺血性中风、颅内出血、蛛网膜下腔出血、糖尿病）、神经炎症性疾病（多发性硬化症、脑传染病、败血症）、神经退行性疾病（阿尔茨海默病、血管性痴呆、衰老）和脑癌（原发性肿瘤、转移）。

更新日期：2018-05-01

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