RhIII‐Catalyzed C−H Activation: Mizoroki–Heck‐Type Reaction of Maleimides,Asian Journal of Organic Chemistry

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RhIII‐Catalyzed C−H Activation: Mizoroki–Heck‐Type Reaction of Maleimides
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-05-30 , DOI: 10.1002/ajoc.201800193
Kiran R. Bettadapur ₁ , Mahadev Sharanappa Sherikar ₁ , Veeranjaneyulu Lanke ₁ , Kandikere Ramaiah Prabhu ₁

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Maleimides are not known to undergo oxidative‐Heck reaction because they lack a syn‐periplanar β‐hydrogen atom. Herein, we report a C−H activation‐based Mizoroki–Heck‐type reaction of maleimides using ketone as the directing group. The reaction utilizes a Rh^III‐catalyst along with Ag₂CO₃ as the oxidant to carry out a base‐mediated formal β‐hydride elimination.

中文翻译：

RhIII催化的CH活化：马来酰亚胺的Mizoroki-Heck型反应

尚不知道马来酰亚胺会发生氧化-Heck反应，因为它们缺乏顺-平面的β-氢原子。在这里，我们报道了以酮为导向基团的基于CH活化的马来酰亚胺的Mizoroki-Heck型反应。该反应利用Rh ^III催化剂和Ag ₂ CO ₃作为氧化剂进行碱介导的形式β-氢化物消除。

更新日期：2018-05-30

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