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Lanostane-type C31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris
Phytochemistry ( IF 3.2 ) Pub Date : 2018-04-30
Jinzhi Zhao, Yun Yang, Mengyao Yu, Ke Yao, Xia Luo, Huayi Qi, Guolin Zhang, Yinggang Luo

Fifteen undescribed and five known lanostane-type C31 triterpenoid derivatives were isolated from the aqueous EtOH extract of the fruiting bodies of cultivated Fomitopsis palustris. Their structures were identified from the spectroscopic data and chemical degradation studies. The structures of palustrisoic acids A and H were confirmed by X-ray crystallography. Polyporenic acid B showed strong cytotoxicity against the HCT116, A549, and HepG2 cell lines with IC50 values of 8.4, 12.1, and 12.2 μM, respectively. Palustrisolides A, C, and G displayed weak cytotoxicity.



中文翻译:

羊毛甾烷-C型31个从培养的子实体三萜系化合物衍生物Fomitopsis沼泽

从栽培的拟南芥(Fomitopsis palustris)子实体的含水EtOH提取物中分离出十五种未描述的和五种已知的羊毛甾烷型C 31三萜类衍生物从光谱数据和化学降解研究确定了它们的结构。X射线晶体学证实了杂多酸A和H的结构。聚孔酸B对HCT116,A549和HepG2细胞系表现出强大的细胞毒性,IC 50值分别为8.4、12.1和12.2μM 。Palustrisolides A,C和G显示出较弱的细胞毒性。

更新日期:2018-04-30
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